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Titolo:
Residues Y429 and Y463 of the human CD5 are targeted by protein tyrosine kinases
Autore:
Vila, JM; Gimferrer, I; Padilla, O; Arman, M; Places, L; Simarro, M; Vives, J; Lozano, F;
Indirizzi:
Hosp Clin Barcelona, IDIBAPS, Serv Immunol, E-08036 Barcelona, Spain Hosp Clin Barcelona Barcelona Spain E-08036 ol, E-08036 Barcelona, Spain
Titolo Testata:
EUROPEAN JOURNAL OF IMMUNOLOGY
fascicolo: 4, volume: 31, anno: 2001,
pagine: 1191 - 1198
SICI:
0014-2980(200104)31:4<1191:RYAYOT>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL ANTIGEN RECEPTOR; HUMAN T-LYMPHOCYTES; SIGNAL-TRANSDUCTION; PHOSPHATIDYLINOSITOL 3-KINASE; NEGATIVE REGULATION; CYTOPLASMIC DOMAIN; B-CELLS; ACTIVATION; PHOSPHORYLATION; ASSOCIATION;
Keywords:
tyrosine phosphorylation; human CD5; Lck; Fyn; lymphocyte activation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Lozano, F Hosp Clin Barcelona, IDIBAPS, Serv Immunol, Villarroel 170, E-08036 Barcelona, Spain Hosp Clin Barcelona Villarroel 170 Barcelona Spain E-08036 pain
Citazione:
J.M. Vila et al., "Residues Y429 and Y463 of the human CD5 are targeted by protein tyrosine kinases", EUR J IMMUN, 31(4), 2001, pp. 1191-1198

Abstract

The human CD5 lymphocyte cell surface cc-receptor modulates activation anddifferentiation responses mediated by the antigen-specific receptor of T and B cells. CD5 is phosphorylated following lymphocyte activation; however,the exact sites and kinases involved are yet to be determined. Jurkat T cell transfectants expressing tyrosine-mutated CD5 molecules have been used to show that residues Y429 and Y463 are targeted in vivo by protein tyrosinekinases following cell stimulation with anti-CD3 mAb or pervanadate. This is in agreement with data from direct in vitro kinase assays using purifiedrecombinant Lck and Fyn protein tyrosine kinases. The analysis of Lck- andCD3-deficient Jurkat cells shows that tyrosine phosphorylation of CD5 requires Lck activity. We propose that T cell activation mediates CD5 tyrosine phosphorylation at residues Y429 and Y463 mainly through the activation of Lck.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 12:35:46