Catalogo Articoli (Spogli Riviste)

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Titolo:
Gastric corpus atrophy following eradication of Helicobacter pylori
Autore:
Larkin, CJ; Watson, P; Sloan, JM; Ardill, JES; Patterson, CC; McCluggage, WG; Buchanan, KD;
Indirizzi:
Royal Victoria Hosp, Wellcome Labs, Dept Med, Belfast BT12 6BA, Antrim, North Ireland Royal Victoria Hosp Belfast Antrim North Ireland BT12 6BA , North Ireland
Titolo Testata:
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
fascicolo: 4, volume: 13, anno: 2001,
pagine: 377 - 382
SICI:
0954-691X(200104)13:4<377:GCAFEO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM GASTRIN; ACID SECRETION; DUODENAL-ULCER; SYDNEY SYSTEM; INFECTION; CANCER; CARCINOMA; MUCOSA; RISK; CLASSIFICATION;
Keywords:
acid secretion; atrophy; eradication therapy; gastrin; Helicobacter pylori; reversibility;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Larkin, CJ Royal Victoria Hosp, Wellcome Labs, Dept Med, Grosvenor Rd, Belfast BT12 6BA, Antrim, North Ireland Royal Victoria Hosp Grosvenor Rd Belfast Antrim North Ireland BT12 6BA
Citazione:
C.J. Larkin et al., "Gastric corpus atrophy following eradication of Helicobacter pylori", EUR J GASTR, 13(4), 2001, pp. 377-382

Abstract

Background Atrophic gastritis can develop in patients with Helicobacter pylori infection leading to a reduction in basal acid output. Whether the atrophy that develops is reversible is controversial. Objective To investigate the effect of H. pylori eradication in infected subjects who had developed atrophy of the corpus mucosa,Method Ten H. pylori positive patients with corpus atrophy were identifiedat oesophagogastroduodenoscopy (OGD). They received eradication therapy with amoxycillin, clarithromycin and omeprazole. Repeat OGD with biopsy was performed at least 3 months later. Fasting plasma gastrin was measured at baseline and at re-endoscopy. H. pylori eradication was confirmed by C-13 urea breath testing. Results Median time to re-endoscopy was 5 months. There was improvement incorpus atrophy in 50% of patients after H. pylori eradication, and a significant reduction in plasma gastrin (P = 0.03). The index patients had a significant diminution of basal acid output compared to controls. Conclusion Corpus atrophy as defined by the Sydney System is reversible insome patients after H. pylori eradication. Improvement in atrophy is associated with a fall in fasting plasma gastrin levels. This may have implications in the prevention of gastric carcinoma. Eur J Gastroenterol Hepatol 13:377-382 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 22:15:44