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Titolo:
Gemcitabine and vinorelbine as first-line chemotherapy for advanced non-small cell lung cancer: a phase II trial
Autore:
Laack, E; Mende, T; Benk, J; Chemaissani, A; Scholtze, J; Lorenz, C; Niestroy, A; Dalhoff, K; Muller, T; Walter, T; Durk, H; Edler, L; Hossfeld, DK;
Indirizzi:
Univ Hamburg, Hosp Eppendorf, Dept Haematol & Oncol, D-20246 Hamburg, Germany Univ Hamburg Hamburg Germany D-20246 l & Oncol, D-20246 Hamburg, Germany Franziskus Hosp, Flenburg, Germany Franziskus Hosp Flenburg GermanyFranziskus Hosp, Flenburg, Germany Hosp Koln Merheim, Cologne, Germany Hosp Koln Merheim Cologne GermanyHosp Koln Merheim, Cologne, Germany Theresien Hosp, Mannheim, Germany Theresien Hosp Mannheim GermanyTheresien Hosp, Mannheim, Germany Hosp Chemnitz, Chemnitz, Germany Hosp Chemnitz Chemnitz GermanyHosp Chemnitz, Chemnitz, Germany Univ Hosp Lubeck, Lubeck, Germany Univ Hosp Lubeck Lubeck GermanyUniv Hosp Lubeck, Lubeck, Germany Hosp Hofheim, Hofheim, Germany Hosp Hofheim Hofheim GermanyHosp Hofheim, Hofheim, Germany Hosp Rosenheim, Rosenheim, Germany Hosp Rosenheim Rosenheim GermanyHosp Rosenheim, Rosenheim, Germany Marien Hosp, Hamm, Germany Marien Hosp Hamm GermanyMarien Hosp, Hamm, Germany German Canc Res Ctr, D-6900 Heidelberg, Germany German Canc Res Ctr Heidelberg Germany D-6900 D-6900 Heidelberg, Germany
Titolo Testata:
EUROPEAN JOURNAL OF CANCER
fascicolo: 5, volume: 37, anno: 2001,
pagine: 583 - 590
SICI:
0959-8049(200103)37:5<583:GAVAFC>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLUS VINORELBINE; CARCINOMA PATIENTS; 2ND-LINE TREATMENT; RANDOMIZED TRIAL; SINGLE-AGENT; STAGE-IIIB; CISPLATIN; COMBINATION; NSCLC; PACLITAXEL;
Keywords:
chemotherapy; gemcitabine; non-small cell lung cancer; phase II trial; vinorelbine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Laack, E Univ Hamburg, Hosp Eppendorf, Dept Haematol & Oncol, Martinistr 52, D-20246 Hamburg, Germany Univ Hamburg Martinistr 52 Hamburg Germany D-20246 burg, Germany
Citazione:
E. Laack et al., "Gemcitabine and vinorelbine as first-line chemotherapy for advanced non-small cell lung cancer: a phase II trial", EUR J CANC, 37(5), 2001, pp. 583-590

Abstract

The purpose of this phase Ii study was to investigate the efficacy and safety of gemcitabine plus vinorelbine as first-line chemotherapy in patients with advanced non-small cell lung cancer (NSCLC). Eligibility criteria included cytologically or histologically confirmed NSCLC (stage IIIB or IV), noprevious chemotherapy, and bidimensionally measurable disease. Patients received 1000 mg/m(2) gemcitabine and 30 mg/m(2) vinorelbine on days 1, 8 and15 every 4 weeks up to eight courses. From December 1997 to November 1998,70 patients (59 stage IV and 11 stage IIIB disease), with a median age of 59 years (range 38-74 years) were enrolled. The intent-to-treat response rate was 41% (95% confidence interval (CI) 30-54%) with 1 complete responder (CR) and 28 partial responders (PRs). 15 patients had stable disease (SD) and 26 progressed (PD). Median survival was 8.3 months (95% CI 6.0-9.9 months), median progression-free survival (PFS) was 4.8 months (95% CI 3.9-5.5 months), and 1-year survival rate was 33.5% (95% CI 24.0-46.8%). Patients received a total of 229 cycles. Haematological and non-haematological toxicities were moderate. Transient World Health Organization (WHO)-grade IV leucopenia and thrombocytopenia occurred in 13 (6%) and two (1%) cycles, respectively. The predominant non-haematological toxicity was local reactions of the veins in 19 (27%) patients (WHO-grade II and III). Neurotoxicity was infrequent, non-cumulative. and reversible. The combination of gemcitabine andvinorelbine has demonstrated activity in metastatic NSCLC. with response and survival rates similar to those of cisplatin-based regimens and a more favourable toxicity profile that is well tolerated in an outpatient setting. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 09:12:48