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Titolo:
Placebo-controlled comparison of dolasetron and metoclopramide in preventing postoperative nausea and vomiting in patients undergoing hysterectomy
Autore:
Piper, SN; Triem, JG; Maleck, WH; Fent, MT; Huttner, I; Boldt, J;
Indirizzi:
Hosp City Ludwigshafen, Dept Anaesthesiol & Intens Care Med, D-67063 Ludwigshafen, Germany Hosp City Ludwigshafen Ludwigshafen Germany D-67063 udwigshafen, Germany
Titolo Testata:
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
fascicolo: 4, volume: 18, anno: 2001,
pagine: 251 - 256
SICI:
0265-0215(200104)18:4<251:PCODAM>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROPHYLACTIC ANTIEMETIC THERAPY; POSTANESTHESIA CARE UNIT; DOSE-RESPONSE TRIAL; GYNECOLOGIC SURGERY; INTRAVENOUS DOLASETRON; ORAL DOLASETRON; DROPERIDOL; GRANISETRON; THYROIDECTOMY; CHEMOTHERAPY;
Keywords:
surgery, hysterectomy; complications, nausea, vomiting; antiemetics, dolasetron, metoclopramide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Piper, SN Klinikum Stadt Ludwigshafen, Dept Anaesthesiol & Intens Care, Bremserstr 79, D-67063 Ludwigshafen, Germany Klinikum Stadt Ludwigshafen Bremserstr 79 Ludwigshafen Germany D-67063
Citazione:
S.N. Piper et al., "Placebo-controlled comparison of dolasetron and metoclopramide in preventing postoperative nausea and vomiting in patients undergoing hysterectomy", EUR J ANAES, 18(4), 2001, pp. 251-256

Abstract

Background and objective In a randomized, placebo-controlled, double-blindtrial, we compared the efficacy of dolasetron and metoclopramide in preventing postoperative nausea and vomiting in women undergoing hysterectomy. Methods Patients were allocated randomly to one of three groups: group A (n = 50) received 50 mg dolasetron orally, group B (n = 50) received 20 mg metoclopramide intravenously and placebo orally, group C (n = 50) received placebo orally. If patients complained of retching or vomiting, or if patients demanded an antiemetic, 1.25 mg droperidol was administrated intravenously. To quantify postoperative nausea and vomiting the following score was used: 0 = no nausea, 1 = nausea, 2 = retching, 3 = single vomiting, 4 = multiple vomiting. The Raatz test was used to analyse postoperative nausea and vomiting (PONV) scores. Results Dolasetron reduced the postoperative nausea and vomiting score significantly (P < 0.02 vs. metoclopramide; P < 0.0001 vs, placebo). Metoclopramide also reduced the postoperative nausea and vomiting score (P < 0.02 vs. placebo). Fisher's exact test showed a significant reduction of vomiting in the dolasetron group compared with metoclopramide-treated patients (P < 0.007) ano placebo-treated patients (P < 0.000006) and a significantly lower rate of nausea in comparison to the placebo group (P < 0.009). There wereno significant differences between the metoclopramide and the placebo groups (in Fisher's exact test). The use of postoperative droperidol per patient was significantly lower in the dolasetron group (P < 0.04 vs. metoclopramide; P < 0.0001 vs. placebo) than in the metoclopramide (P < 0.02 vs. placebo) and in groups. Conclusions Oral dolasetron is more effective than either metoclopramide given intravenously or placebo for preventing vomiting after hysterectomy. It also was significantly superior to either metoclopramide or placebo concerning the PONV score and the need for droperidol rescue.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/08/20 alle ore 12:59:46