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Titolo:
Dipole localization for identification of neuronal generators in independent neighboring interictal EEG spike foci
Autore:
Ochi, A; Otsubo, H; Chitoku, S; Hunjan, A; Sharma, R; Rutka, JT; Chuang, SH; Kamijo, I; Yamazaki, T; Snead, OC;
Indirizzi:
Hosp Sick Children, Div Neurol, Dept Paediat, Toronto, ON M5G 1X8, Canada Hosp Sick Children Toronto ON Canada M5G 1X8 Toronto, ON M5G 1X8, Canada Hosp Sick Children, Dept Diagnost Imaging, Toronto, ON M5G 1X8, Canada Hosp Sick Children Toronto ON Canada M5G 1X8 Toronto, ON M5G 1X8, Canada Hosp Sick Children, Bloorview Epilepsy Res Program, Toronto, ON M5G 1X8, Canada Hosp Sick Children Toronto ON Canada M5G 1X8 Toronto, ON M5G 1X8, Canada Hosp Sick Children, Div Neurosurg, Dept Surg, Toronto, ON M5G 1X8, Canada Hosp Sick Children Toronto ON Canada M5G 1X8 Toronto, ON M5G 1X8, Canada Univ Toronto, Toronto, ON, Canada Univ Toronto Toronto ON CanadaUniv Toronto, Toronto, ON, Canada NEC Corp Ltd, Fundamental Res Labs, Tsukuba, Ibaraki 305, Japan NEC Corp Ltd Tsukuba Ibaraki Japan 305 Labs, Tsukuba, Ibaraki 305, Japan
Titolo Testata:
EPILEPSIA
fascicolo: 4, volume: 42, anno: 2001,
pagine: 483 - 490
SICI:
0013-9580(200104)42:4<483:DLFION>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPILEPSY; ELECTROENCEPHALOGRAPHY; POTENTIALS;
Keywords:
tangential dipole; phase reversal; EEG; dipole orientation; children;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Ochi, A Hosp Sick Children, Div Neurol, Dept Paediat, 555 Univ Ave, Toronto, ON M5G 1X8, Canada Hosp Sick Children 555 Univ Ave Toronto ON Canada M5G1X8 , Canada
Citazione:
A. Ochi et al., "Dipole localization for identification of neuronal generators in independent neighboring interictal EEG spike foci", EPILEPSIA, 42(4), 2001, pp. 483-490

Abstract

Purpose: We evaluated dipole localizations of independent neighboring interictal spike foci using scalp electroencephalogram (EEG) to identify neuronal generators of epileptic discharges. Methods: Three pediatric patients with extratemporal lobe epilepsy who hadtwo independent neighboring interictal spike foci on scalp EEG were studied. prolonged video EEG was digitally recorded from 19 scalp electrodes, whose positions were registered using a three-dimensional digitizer. Interictal spikes were visually selected based on negative phase reversals on bipolar montages. We analyzed the dipole position and moment of each spike using a single moving dipole and three-shell spherical head model. The dipoles were overlaid onto magnetic resonance (MR) images and divided into two groupsbased on two spike foci. Results: The dipoles of the two groups were oriented either tangentially or radially to the scalp in close proximity to each other. The dipoles oriented radially were located underneath the electrode with a negative peak; those oriented tangentially were between electrodes with a negative and positive peak. The positions of tangential dipoles were more concentrated than those of radial dipoles. The epileptogenic regions corresponded to the dipole localizations. Surgical excisions were performed based on the results of electrocorticography. After surgery, two patients were seizure free. and one had rare seizures (follow-up period, 13-31 months). Conclusions: We showed that dipoles in close proximity but with different orientations projected two negative maxima on scalp EEG in three patients with extratemporal localization-related epilepsy. Equivalent current dipole analysis of individual interictal spikes can provide useful information about the epileptogenic zone in these patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 08:31:48