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Titolo:
Opioids, opioid receptors, and the immune response
Autore:
McCarthy, L; Wetzel, M; Sliker, JK; Eisenstein, TK; Rogers, TJ;
Indirizzi:
Temple Univ, Sch Med, Dept Microbiol & Immunol, Philadelphia, PA 19140 USATemple Univ Philadelphia PA USA 19140 Immunol, Philadelphia, PA 19140 USA Temple Univ, Sch Med, Ctr Subst Abuse Res, Philadelphia, PA 19140 USA Temple Univ Philadelphia PA USA 19140 use Res, Philadelphia, PA 19140 USA Temple Univ, Sch Med, Fels Inst Canc Res & Mol Biol, Philadelphia, PA 19140 USA Temple Univ Philadelphia PA USA 19140 ol Biol, Philadelphia, PA 19140 USA
Titolo Testata:
DRUG AND ALCOHOL DEPENDENCE
fascicolo: 2, volume: 62, anno: 2001,
pagine: 111 - 123
SICI:
0376-8716(20010401)62:2<111:OORATI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN POLYMORPHONUCLEAR LEUKOCYTES; MORPHINE-INDUCED ALTERATIONS; MACROPHAGE CELL-LINE; BETA-ENDORPHIN; BINDING-SITES; IN-VITRO; T-CELLS; OPIATE RECEPTOR; AGONIST U50,488H; MESSENGER-RNA;
Keywords:
opiate abuse; immune function; immunobiology; molecular biology; HIV review;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
133
Recensione:
Indirizzi per estratti:
Indirizzo: Rogers, TJ Temple Univ, Sch Med, Dept Microbiol & Immunol, 3400 N Broad St, Philadelphia, PA 19140 USA Temple Univ 3400 N Broad St Philadelphia PA USA 19140 19140 USA
Citazione:
L. McCarthy et al., "Opioids, opioid receptors, and the immune response", DRUG AL DEP, 62(2), 2001, pp. 111-123

Abstract

It is now clear that opioid receptors participate in the function of the cells of the immune system, and evidence suggests that opioids modulate bothinnate and acquired immune responses. We review literature here which establishes that mu-, kappa-, and delta -opioid compounds alter resistance to avariety of infectious agents, including the Human Immunodeficiency Virus (HIV). The nature of the immunomodulatory activity of the opioids has been the subject of a great deal of research over the last ten years. There is increasing evidence that effects of opioids on the immune response are mediated at several levels. Modulation of the inflammatory response appears to bea target of these compounds. including effects on phagocytic activity, as well as the response of cells to various chemoattractant molecules. Moreover, findings from several laboratories have demonstrated the impact of opioid treatment on antibody responses, and the molecular basis for this effect is likely due, at least in part, to the modulation of both cytokine and cytokine receptor expression. Future research should provide a clearer understanding of the cellular and molecular targets of opioid action within the immune system. (C) 2001 Elsevier science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:23:33