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Titolo:
The effects of chronic morphine on behavior reinforced by several opioids or by cocaine in rhesus monkeys
Autore:
Winger, G; Woods, JH;
Indirizzi:
Univ Michigan, Dept Pharmacol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 t Pharmacol, Ann Arbor, MI 48109 USA Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 ept Psychol, Ann Arbor, MI 48109 USA
Titolo Testata:
DRUG AND ALCOHOL DEPENDENCE
fascicolo: 3, volume: 62, anno: 2001,
pagine: 181 - 189
SICI:
0376-8716(20010501)62:3<181:TEOCMO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY DEPRESSION; CROSS-TOLERANCE; MU-OPIOIDS; RATS; ANTINOCICEPTION; NALTREXONE; ANTAGONISM; WITHDRAWAL; ANALGESIA; INFUSION;
Keywords:
tolerance; opioids; rhesus monkeys; self-administration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Winger, G Univ Michigan, Dept Pharmacol, 1501 W Med Ctr Dr, Ann Arbor, MI 48109 USA Univ Michigan 1501 W Med Ctr Dr Ann Arbor MI USA 48109 48109 USA
Citazione:
G. Winger e J.H. Woods, "The effects of chronic morphine on behavior reinforced by several opioids or by cocaine in rhesus monkeys", DRUG AL DEP, 62(3), 2001, pp. 181-189

Abstract

The reinforcing effects of intravenously delivered cocaine, alfentanil, morphine, heroin, nalbuphine, or buprenorphine were evaluated in four rhesus monkeys before, during, and after daily administration of 3.2 mg/kg morphine. Morphine was given 21 h prior to measures of the reinforcing effects of each of the drugs. No changes in the potency of cocaine or the high efficacy mu agonist alfentanil were detectable during the period of chronic morphine administration. Small (1/2-1) log unit decreases in the reinforcing potency of intermediate efficacy mu agonists morphine and heroin occurred during chronic morphine administration. Larger decreases in both the potency andeffectiveness of low-efficacy mu agonists nalbuphine and buprenorphine developed during this time. These data suggest that the amount of tolerance that develops to the reinforcing effects of opioids depends on the efficacy of the drugs used to maintain responding. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 14:38:09