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Titolo:
Genes in drug abuse
Autore:
Kuhar, MJ; Joyce, A; Dominguez, G;
Indirizzi:
Emory Univ, Yerkes Reg Primate Res Ctr, Atlanta, GA 30329 USA Emory Univ Atlanta GA USA 30329 eg Primate Res Ctr, Atlanta, GA 30329 USA
Titolo Testata:
DRUG AND ALCOHOL DEPENDENCE
fascicolo: 3, volume: 62, anno: 2001,
pagine: 157 - 162
SICI:
0376-8716(20010501)62:3<157:GIDA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMPHETAMINE-REGULATED TRANSCRIPT; BRAIN MESSENGER-RNA; NUCLEUS-ACCUMBENS; CHRONIC COCAINE; RAT-BRAIN; LOCOMOTOR-ACTIVITY; HYPOTHALAMIC CART; RECEPTOR-BINDING; EXPRESSION; ADDICTION;
Keywords:
drug abuse; genes; gene expression; CART;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Kuhar, MJ Emory Univ, Yerkes Reg Primate Res Ctr, 954 Gatewood Rd NE, Atlanta, GA 30329 USA Emory Univ 954 Gatewood Rd NE Atlanta GA USA 30329 GA 30329 USA
Citazione:
M.J. Kuhar et al., "Genes in drug abuse", DRUG AL DEP, 62(3), 2001, pp. 157-162

Abstract

Because of the genome projects it will be possible to identify the changesin gene expression that are associated with drug abuse. The ultimate goal will be to determine the role and significance of the gene products. To date about 100 genes have been found with altered expression after administration of drugs. The development of new technologies such as microarrays will greatly facilitate finding such changes in expression. The rate at which levels of some gene products change is compatible with the time course of development of dependence in animals, but we must be able to establish a cause-effect relationship between genes and drug abuse, which this will be difficult. The product of the novel cocaine and amphetamine regulated transcript(CART) gene is a useful example where a gene product has been associated with drug abuse. CART was identified as an mRNA that changed in response to psychostimulant drug administration and injection of CART peptides into thevental tegmental area produces psychostimulant-like effects. Definitive evidence, if obtainable, that specific genes are responsible for vulnerability to drug abuse could have dramatic effects on public health policy. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:09:41