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Titolo:
Role of fibrates and HMG-CoA reductase inhibitors in gallstone formation epidemiological - Study in an unselected population
Autore:
Caroli-Bosc, FX; Le Gall, P; Pugliese, P; Delabre, B; Caroli-Bosc, C; Demarquary, JF; Delmont, JP; Rampal, P; Montet, JC;
Indirizzi:
Univ Nice, Hop Archet 2, Federat Malad Appareil Digest, F-06202 Nice 3, France Univ Nice Nice France 3 at Malad Appareil Digest, F-06202 Nice 3, France Hop St Marguerite, INSERM, Hepatol Unit, Marseille, France Hop St Marguerite Marseille France ERM, Hepatol Unit, Marseille, France
Titolo Testata:
DIGESTIVE DISEASES AND SCIENCES
fascicolo: 3, volume: 46, anno: 2001,
pagine: 540 - 544
SICI:
0163-2116(200103)46:3<540:ROFAHR>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
BILE LIPID-COMPOSITION; COENZYME-A REDUCTASE; CHOLESTEROL GALLSTONE; COMPETITIVE INHIBITOR; SOUTHEAST FRANCE; TERM TREATMENT; RISK-FACTORS; GALL-STONES; DISEASE; SIMVASTATIN;
Keywords:
gallstones; HMG-CoA reductase inhibitors; fibrates;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Caroli-Bosc, FX Univ Nice, Hop Archet 2, Federat Malad Appareil Digest, 151 Route St Antoine Ginestiere, F-06202 Nice 3, France Univ Nice 151 Route St Antoine Ginestiere Nice France 3 e
Citazione:
F.X. Caroli-Bosc et al., "Role of fibrates and HMG-CoA reductase inhibitors in gallstone formation epidemiological - Study in an unselected population", DIG DIS SCI, 46(3), 2001, pp. 540-544

Abstract

Fibrate derivatives and HMG-CoA reductase inhibitors modify homeostasis ofcholesterol. The aim of this study was to assess in an unselected population whether these hypolipidemic drugs are risk factors for cholelithiasis or, conversely, are protective agents. Both sexes, all socioeconomic categories, pregnant women and cholecystectomized subjects were included. Clinical data collection and gallbladder ultrasonography were both carried out in a double-blind fashion. Fibrate derivatives were predominantly fenofibrate, HMG-CoA reductase inhibitors were simvastatin and pravastatin. On univariateanalysis, age (>50 years), sex, and use of fibrates were found to be significantly related to the presence of cholelithiasis. Age, sex, and fibrate treatment remained independently correlated with the presence of gallstones on multivariate analysis. With fibrates, the relative risk for lithiasis was 1.7 (P = 0.04). The HMG-CoA reductase inhibitors were not associated witha protective effect on univariate analysis. Of the lipid-lowering drugs, only fibrate derivatives were found to increase the risk of gallstone formation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 10:13:13