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Titolo:
Inhibition of intestinal cholesterol absorption by surfomer [alpha-olefin maleic acid] affects hepatic cholesterol synthesis and low density lipoprotein transport in hamsters fed a fat-enriched diet
Autore:
Bertolotti, M; Spady, DK;
Indirizzi:
Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX USA Univ Texas Dallas TX USA , SW Med Ctr, Dept Internal Med, Dallas, TX USA Univ Modena & Reggio Emilia, Dept Internal Med, Modena, Italy Univ Modena & Reggio Emilia Modena Italy pt Internal Med, Modena, Italy
Titolo Testata:
DIGESTIVE AND LIVER DISEASE
fascicolo: 2, volume: 33, anno: 2001,
pagine: 145 - 150
SICI:
1590-8658(200103)33:2<145:IOICAB>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
BILIARY CHOLESTEROL; STEROL SYNTHESIS; SYNTHESIS INVIVO; LOWERING ACTION; IN-VIVO; RAT; METABOLISM; LIVER; TISSUES; SITES;
Keywords:
cholesterol homeostasis; cholesterol synthesis; low density lipoprotein transport; surfomer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Bertolotti, M Div Med 3, Dipartimento Med Interna, Via Pozzo 71, I-41100 Modena, Italy Div Med 3 Via Pozzo 71 Modena Italy I-41100 0 Modena, Italy
Citazione:
M. Bertolotti e D.K. Spady, "Inhibition of intestinal cholesterol absorption by surfomer [alpha-olefin maleic acid] affects hepatic cholesterol synthesis and low density lipoprotein transport in hamsters fed a fat-enriched diet", DIG LIVER D, 33(2), 2001, pp. 145-150

Abstract

Background, Surfomer (alpha -olefin maleic acid) reduces intestinal cholesterol absorption. Aims. This study was performed to investigate the effect of surfomer on cholesterol synthesis and low density lipoprotein in hamsters fed a hypercholesterolaemic, lipid-enriched diet. Animals and methods. Male hamsters were fed a diet enriched in cholesterol(0.07%) and saturated fatty acids (coconut oil 20%); the diet was supplemented with 3% surfomer: for 1-4 weeks. Cholesterol synthesis was assessed measuring incorporation of [H-3]water into tissue sterols; low density lipoprotein clearance was determined using a primed-continuous infusion of [I-125]tyramine-cellobiose lipoprotein. Results. Cholesterol synthesis was suppressed after 3 weeks of hyperlipidaemic diet in liver and small bowel (by 88% and 38%, respectively) and was significantly increased by supplementing the fat-enriched diet with surfomer. Low density lipoprotein-cholesterol was increased by 44% after 4 weeks ofhyperlipidaemic diet, in parallel with a decrease in hepatic low density lipoprotein clearance rates (48 +/-3 vs 68 +/-7 mul of plasma/h per g of tissue). Concurrent treatment with surfomer for 1, P or 4 weeks prevented the decrease of clearance and maintained normal low density lipoprotein-cholesterol levels at all time points,Conclusions. Surfomer represents a powerful tool to investigate the impactof cholesterol absorption on sterol homeostasis. Furthermore, since surfomer appears to normalize low density lipoprotein transport in hamsters fed adiet comparable to a lipid-rich "western-style" regimen, this drug may deserve consideration as an adjunct treatment for hypercholesterolaemia in selected patient groups.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 07:10:41