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OPAC HELP

Titolo:
Randomised study of the efficacy of Omeprazole and Clarithromycin with either Amoxycillin or Metronidazole in the eradication of Helicobacter pylori in screened primary care patients
Autore:
Neville, PM; Barrowclough, S; Crocombe, W; Axon, ATR; Wrangstadh, M; Moayyedi, P;
Indirizzi:
Gen Infirm Leeds, Ctr Digest Dis, Leeds, W Yorkshire, England Gen Infirm Leeds Leeds W Yorkshire England , Leeds, W Yorkshire, England Univ Leeds, No & Yorkshire Clin Trials & Res Unit, Leeds LS2 9JT, W Yorkshire, England Univ Leeds Leeds W Yorkshire England LS2 9JT S2 9JT, W Yorkshire, England AstraZeneca, Molndal, Sweden AstraZeneca Molndal SwedenAstraZeneca, Molndal, Sweden
Titolo Testata:
DIGESTIVE AND LIVER DISEASE
fascicolo: 2, volume: 33, anno: 2001,
pagine: 131 - 134
SICI:
1590-8658(200103)33:2<131:RSOTEO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRIPLE THERAPY; DUAL THERAPY; COMMUNITY; EPIDEMIOLOGY; POPULATION; DYSPEPSIA; REGIMEN;
Keywords:
Helicobacter pylori drug therapy; mass screening; middle age; proton pump inhibitors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Neville, PM Nevill Hall Hosp, Brecon Rd, Abergavenny, Mons, England NevillHall Hosp Brecon Rd Abergavenny Mons England , England
Citazione:
P.M. Neville et al., "Randomised study of the efficacy of Omeprazole and Clarithromycin with either Amoxycillin or Metronidazole in the eradication of Helicobacter pylori in screened primary care patients", DIG LIVER D, 33(2), 2001, pp. 131-134

Abstract

Background. Population Helicobacter pylori screening and treatment has been advocated as a means of reducing mortality from gastric cancer. The optimum Helicobacter pylori eradication therapy to use in this setting is uncertain. Aims. To compare efficacy of seven days of omeprazole, clarithromycin and either metronidazole, or amoxycillin in Helicobacter pylori positive subjects detected by population screening. Patients. Helicobacter pylori positive patients from the placebo group of a population screening and treatment trial were invited to take part in theinvestigation. Methods, Patients were randomised to receive either omeprazole, clarithromycin and metronidazole or omeprazole, clarithromycin and amoxycillin, and Helicobacter pylori eradication was verified with a C-13-urea breath test atleast four weeks after completion of therapy. Results, A total of 221 patients took part in the study and 210 completed the protocol. Treatment was successful in 93/111 (84%) patients allocated to omeprazole, clarithromycin and metronidazole and in 96/110 (87%) allocated to omeprazole, clarithromycin and amoxycillin in an intention-to-treat analysis (p=0.46). Per protocol eradication rates were 93/107 (87%) in the metronidazole, and 96/103 (93%) amoxycillin group (p=0.129). Conclusions, There was no significant difference between the two regimens. The eradication rates achieved are comparable with previous studies in both dyspepsia and peptic ulcer patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:00:00