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Titolo:
Effects of the Magenstrasse and Mill operation for obesity on plasma leptin and insulin resistance
Autore:
Carmichael, AR; Johnston, D; King, RFGJ; Sue-Ling, HM;
Indirizzi:
Leeds Gen Infirm, Acad Dept Surg, Leeds, W Yorkshire, England Leeds Gen Infirm Leeds W Yorkshire England , Leeds, W Yorkshire, England Leeds Gen Infirm, Ctr Digest Dis, Leeds, W Yorkshire, England Leeds Gen Infirm Leeds W Yorkshire England , Leeds, W Yorkshire, England
Titolo Testata:
DIABETES OBESITY & METABOLISM
fascicolo: 2, volume: 3, anno: 2001,
pagine: 99 - 103
SICI:
1462-8902(200104)3:2<99:EOTMAM>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
BODY-WEIGHT; DIABETES-MELLITUS; GENE-EXPRESSION; NEUROPEPTIDE-Y; OB/OB MICE; IN-VITRO; DISEASE; ADIPOSITY; PROTEIN; GLUCOSE;
Keywords:
Magenstrasse and Mill operation; obesity; plasma leptin; insulin resistance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Carmichael, AR 19 Water Meadows, Canterbury CT2 0BF, Kent, England 19 Water Meadows Canterbury Kent England CT2 0BF , England
Citazione:
A.R. Carmichael et al., "Effects of the Magenstrasse and Mill operation for obesity on plasma leptin and insulin resistance", DIABET OB M, 3(2), 2001, pp. 99-103

Abstract

Background: We evaluated the effect of the Magenstrasse and Mill (M & M) operation-a new form of non-banded vertical gastroplasty-on weight loss, plasma leptin levels and insulin resistance. Methods: Fasting plasma glucose, leptin and insulin levels were measured in 12 normal controls, 39 morbidly obese patients and 39 patients a median 3years after the M & M procedure. Insulin resistance was calculated by the homeostasis model insulin resistance index. Results: Body mass index mean (s.d.) decreased significantly (p < 0.0001),from 48(7) to 33(5) kg/m(2), after the M & M procedure. Fasting plasma leptin concentration in the morbidly obese group was 37.9(15.4) ng/ml, significantly (p < 0.0001) higher than the control group (12.2(8.4)) and the M & Mgroup (19.1(12.7)) ng/ml. Fasting plasma insulin concentrations were also significantly (p < 0.0001) higher in the morbidly obese group compared withthan in the M & M group or in the control group: 35.5(22.3) mU/l, 15.5(7.1) mU/l and 13.6(3.4) mU/l, respectively. Insulin resistance was 9.6(7.2) inthe morbidly obese group and 3.5(1.9) in the M & M group (p < 0.0001). Conclusion: This is one of the first studies to show that the decrease in insulin resistance after weight loss achieved by anti-obesity surgery is associated with significantly lower levels of plasma leptin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 18:17:36