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Titolo:
The AraC transcriptional activators
Autore:
Martin, RG; Rosner, JL;
Indirizzi:
NIDDKD, Mol Biol Lab, NIH, Bethesda, MD 20892 USA NIDDKD Bethesda MD USA 20892 D, Mol Biol Lab, NIH, Bethesda, MD 20892 USA
Titolo Testata:
CURRENT OPINION IN MICROBIOLOGY
fascicolo: 2, volume: 4, anno: 2001,
pagine: 132 - 137
SICI:
1369-5274(200104)4:2<132:TATA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE ANTIBIOTIC-RESISTANCE; AMP RECEPTOR PROTEIN; ESCHERICHIA-COLI; DNA-BINDING; INDUCIBLE PROMOTERS; VIRULENCE REGULATOR; RNA-POLYMERASE; FAMILY; SITE; MARA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Martin, RG NIDDKD, Mol Biol Lab, NIH, Bethesda, MD 20892 USA NIDDKD Bethesda MD USA 20892 Lab, NIH, Bethesda, MD 20892 USA
Citazione:
R.G. Martin e J.L. Rosner, "The AraC transcriptional activators", CURR OPIN M, 4(2), 2001, pp. 132-137

Abstract

The AraC family of bacterial transcriptional activators regulate diverse genetic systems. Recent X-ray diffraction studies show that the monomeric MarA and Rob activators bind to their asymmetric degenerate DNA sites via twodifferent helix-turn-helix elements. Activation by MarA! SoxS or Rob requires a particular orientation of the asymmetric, binding sequence (and hencethe activator), depending on its distance from the -10 RNAP signal. Genetic studies are beginning to clarify how the activators interact with RNAP. Growing evidence suggests that for the sugar metabolism activators, multiplebinding sites upstream of the promoter anchor the activator in a repressing or nonactivating configuration. By interaction with the sugar and/or CRP,the activator is allosterically altered so it can bind a new set of sites that enable it to activate the promoter. Surprisingly, the virulence activator, Rns, must bind to both upstream and downstream sites in order to activate the ms promoter.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 12:12:39