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Titolo:
Transcription elongation complex: structure and function
Autore:
Korzheva, N; Mustaev, A;
Indirizzi:
Publ Hlth Res Inst, New York, NY 10016 USA Publ Hlth Res Inst New York NYUSA 10016 Res Inst, New York, NY 10016 USA
Titolo Testata:
CURRENT OPINION IN MICROBIOLOGY
fascicolo: 2, volume: 4, anno: 2001,
pagine: 119 - 125
SICI:
1369-5274(200104)4:2<119:TECSAF>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLI RNA-POLYMERASE; ESCHERICHIA-COLI; NASCENT RNA; DNA HYBRID; TERMINATION; MECHANISM; TRANSLOCATION; ORGANIZATION; PROCESSIVITY; CLEAVAGE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Korzheva, N Publ Hlth Res Inst, 455 1st Ave, New York, NY 10016 USA Publ Hlth Res Inst 455 1st Ave New York NY USA 10016 10016 USA
Citazione:
N. Korzheva e A. Mustaev, "Transcription elongation complex: structure and function", CURR OPIN M, 4(2), 2001, pp. 119-125

Abstract

Our understanding of the mechanisms of transcription has been greatly advanced by recent determination of the X-ray structure of bacterial RNA polymerase. Using crosslinking approaches, extensive mapping of DNA and RNA contacts onto this structure allowed tracking of the path of nucleic acids through the transcription elongation complex. The resulting structural model of the transcription elongation complex is linked to the functional one, whichis based on numerous data accumulated during previous studies of RNA synthesis. An integrated structure-function model allows the rational explanation of termination and pausing and provides new insights into the mechanisms of transcription.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:46:16