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Titolo:
Chemotactic selection with insulin, di-iodotyrosine and histamine alters the phagocytotic responsiveness of Tetrahymena
Autore:
Schiess, N; Csaba, G; Kohidai, L;
Indirizzi:
Semmelweis Univ Med, Dept Genet Cell & Immunobiol, H-1445 Budapest, Hungary Semmelweis Univ Med Budapest Hungary H-1445 ol, H-1445 Budapest, Hungary
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
fascicolo: 4, volume: 128, anno: 2001,
pagine: 521 - 530
SICI:
1532-0456(200104)128:4<521:CSWIDA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PYRIFORMIS; CYTOKINES; PHYLOGENY;
Keywords:
phagocytosis; chemotactic selection; insulin; histamine; Tetrahymena;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Csaba, G Semmelweis Univ Med, Dept Genet Cell & Immunobiol, POB 370, H-1445 Budapest, Hungary Semmelweis Univ Med POB 370 Budapest Hungary H-1445 est, Hungary
Citazione:
N. Schiess et al., "Chemotactic selection with insulin, di-iodotyrosine and histamine alters the phagocytotic responsiveness of Tetrahymena", COMP BIOC C, 128(4), 2001, pp. 521-530

Abstract

Chemotactic selection is a method by which populations of cells exposed toligands can be isolated and subsequently cultivated. We used Tetrahymena pyriformis GL cultures selected by chemotactic selection to insulin (10 nM),histamine (0.1 nM) and di-iodotyrosine (T2, 10 nM) to study the phagocytotic capacity under the induction of selector hormones. Our results show a long-lasting link between chemotactically selected cultures and phagocytotic activity. Cells selected to histamine produced the highest phagocytotic activity upon a second exposure to the selector hormone. T2 selection was alsostrongly effective, however, the phagocytosis stimulation was not specificto the hormone given later. Insulin selected sub-populations had differentphagocytotic responses to the control substance itself, whereas histamine selected sub-populations seem to be heterogeneous in the phagocytotic response to histamine. For insulin, the increased endocytotic or metabolic activity was demonstrated by the lack of non-phagocytotic cells. These experiments call attention to the evolutionary role of selection in the later developing receptor-hormone relationship. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 12:01:59