Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Ouabain-sensitive and insensitive acetylcholine receptors on the membrane of the same neuron in Helix pomatia
Autore:
Grigorian, KP; Azatyan, KV; Kazaryan, SH; Ayrapetyan, SN;
Indirizzi:
Life Sci Int Educ Ctr, Yerevan 375014, Armenia Life Sci Int Educ Ctr Yerevan Armenia 375014 tr, Yerevan 375014, Armenia Natl Acad Sci, Inst Fine Organ Chem, Yerevan, Armenia Natl Acad Sci Yerevan Armenia i, Inst Fine Organ Chem, Yerevan, Armenia
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
fascicolo: 4, volume: 128, anno: 2001,
pagine: 511 - 520
SICI:
1532-0456(200104)128:4<511:OAIARO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLINORECEPTORS;
Keywords:
acetylcholine; structural analogs of acetylcholine; choline esters; chemoreceptive properties; muscarinic receptors; nicotinic receptors; ionic currents; Na-K pump; ouabain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Ayrapetyan, SN Life Sci Int Educ Ctr, Hasratian St 7, Yerevan 375014, Armenia Life Sci Int Educ Ctr Hasratian St 7 Yerevan Armenia 375014
Citazione:
K.P. Grigorian et al., "Ouabain-sensitive and insensitive acetylcholine receptors on the membrane of the same neuron in Helix pomatia", COMP BIOC C, 128(4), 2001, pp. 511-520

Abstract

Using internally dialyzed neurons of Helix pomatia as a model, the effect of structural analogs of acetylcholine (ACh) were investigated for their cholinomimetic properties on A- and B-types of ACh-responses. Specifically weanalyzed choline esters of N-para- and ortho-alkoxybenzoyl-beta -alanines,(CH3O-, C2H5O-, C3H7O-, iso-C3H7O-, C4H9O-, iso-C4H9O-, C5H11O-, iso-C5H11O-), (in all, 16 combinations). The compounds evoked differing sensitivities of response to factors de-activating the Na-K-pump (ouabain and K-free solution), Most compounds resembled ACh: ionic currents caused by these compounds were inhibited by Na-K pump blockers in the case of A-type responses -B-type responses were insensitive to these factors. Ionic currents inducedby choline esters of p-, o-propoxy- and iso-propoxybenzoyl-beta -alanines were insensitive to ouabain and K-free solution in the case of A- and B-type responses. Ionic currents induced by the choline ester of p-butoxybenzoyl-beta -alanine were inhibited by ouabain and K-free solution on both types of neuron. The results allow us to classify choline eaters of p-, o-propoxy- and iso-propoxybenzoyl-beta -alanines as N-cholinomimetics, while the choline ester of p-butoxybenzoyl-beta -alanine can be considered as M-cholinomimetic. We conclude that both M- and N-type ACh receptors exist on the membrane of the same neurons. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:42:17