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Titolo:
Oxidative stress, microsomal and peroxisomal fatty acid oxidation in the liver of rats treated with acetone
Autore:
Orellana, M; Guajardo, V; Araya, J; Thieleman, L; Rodrigo, R;
Indirizzi:
Univ Chile, Fac Med, ICBM, Programa Farmacol Mol & Clin, Santiago 7, ChileUniv Chile Santiago Chile 7 grama Farmacol Mol & Clin, Santiago 7, Chile
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
fascicolo: 4, volume: 128, anno: 2001,
pagine: 503 - 509
SICI:
1532-0456(200104)128:4<503:OSMAPF>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
N-NITROSODIMETHYLAMINE DEMETHYLASE; CHRONIC ETHANOL-CONSUMPTION; CYTOCHROME-P450 2E1; OMEGA-OXIDATION; BETA-OXIDATION; METABOLISM; KIDNEY; INDUCTION; PROLIFERATORS; GLUTATHIONE;
Keywords:
acetone; aminopyrine; cytochrome P450; lauric acid; liver; oxidative stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Orellana, M Univ Chile, Fac Med, ICBM, Programa Farmacol Mol & Clin, Casilla 70086, Santiago 7, Chile Univ Chile Casilla 70086 Santiago Chile 7 , Santiago 7, Chile
Citazione:
M. Orellana et al., "Oxidative stress, microsomal and peroxisomal fatty acid oxidation in the liver of rats treated with acetone", COMP BIOC C, 128(4), 2001, pp. 503-509

Abstract

Parameters of oxidative stress, microsomal cytochrome P450 activity and peroxisomal fatty acid oxidation were studied in liver of rats following acetone (1% v/v) consumption for 7 days. Acetone treatment increased the activity of catalase and decreased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GTPx), but did not significantly modify the liver content of malondialdehyde (MDA) and reduced glutathione. Also, acetone increased the total content of cytochrome P450, the microsomal lauric acid hydroxylation, aminopyrine N-demethylation and the peroxisomal beta -oxidation of palmitoyl CoA. These effects were similar to those found previously in starved and ethanol-treated rats, supporting the hypothesis that ketone bodies would be the common inducer of microsomal and peroxisomal fatty acid oxidation in these metabolic states. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:22:02