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Titolo:
Dynamic changes in mouse lipoproteins induced by transiently expressed human phospholipid transfer protein (PLTP): importance of PLTP in pre beta-HDLgeneration
Autore:
Jaari, S; van Dijk, KW; Olkkonen, VM; van der Zee, A; Metso, J; Havekes, L; Jauhiainen, M; Ehnholm, C;
Indirizzi:
Natl Publ Hlth Inst, Dept Biochem, SF-00300 Helsinki, Finland Natl Publ Hlth Inst Helsinki Finland SF-00300 SF-00300 Helsinki, Finland TNO Prevent & Hlth, Gaubius Lab, Leiden, Netherlands TNO Prevent & Hlth Leiden Netherlands Gaubius Lab, Leiden, Netherlands
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
fascicolo: 4, volume: 128, anno: 2001,
pagine: 781 - 792
SICI:
1096-4959(200104)128:4<781:DCIMLI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEIN; LECITHIN-CHOLESTEROL ACYLTRANSFERASE; ADENOVIRUS-MEDIATED OVEREXPRESSION; ESTER TRANSFER PROTEIN; APOLIPOPROTEIN-A-I; HUMAN-PLASMA; HEPATIC LIPASE; TRANSGENIC MICE; LPA-I; PARTICLES;
Keywords:
adenovirus vector; apolipoprotein; HDL metabolism; lipoprotein; PLTP; reverse cholesterol transport;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Ehnholm, C Natl Publ Hlth Inst, Dept Biochem, Mannerheimintie 166, SF-00300 Helsinki,Finland Natl Publ Hlth Inst Mannerheimintie 166 Helsinki Finland SF-00300
Citazione:
S. Jaari et al., "Dynamic changes in mouse lipoproteins induced by transiently expressed human phospholipid transfer protein (PLTP): importance of PLTP in pre beta-HDLgeneration", COMP BIOC B, 128(4), 2001, pp. 781-792

Abstract

The plasma phospholipid transfer protein (PLTP) plays an important role inthe regulation of plasma high density lipoprotein (HDL) levels and governsthe distribution of HDL sub-populations. In the present study, adenovirus mediated overexpression of human PLTP in mice was employed to investigate the distribution of PLTP in serum and its effect on plasma lipoproteins. Gelfiltration experiments showed that the distributions of PLTP activity and mass in serum are different, suggesting that human PLTP circulated in mouseplasma as two distinct forms, one with high and the other with low specific activity. Our study further demonstrates that overexpression of PLTP leads to depletion of HDL and that, as PLTP activity declines, replenishment ofthe HDL fraction occurs. During this process, the lipoprotein profile displays transient particle populations, including apoA-IV and apoE-rich particles in the LDL size range and small particles containing apoA-II only. The possible role of these particles in HDL reassembly is discussed. The increased PLTP activity enhanced the ability of mouse sera to produce prep-HDL. The present results provide novel evidence that PLTP is an important regulator of HDL metabolism and plays a central role in the reverse cholesterol transport (RCT) process. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 20:58:45