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Titolo:
The heartbeat-evoked brain potential in patients suffering from diabetic neuropathy and in healthy control persons
Autore:
Leopold, C; Schandry, R;
Indirizzi:
Univ Munich, Inst Psychol, D-80802 Munich, Germany Univ Munich Munich Germany D-80802 Inst Psychol, D-80802 Munich, Germany
Titolo Testata:
CLINICAL NEUROPHYSIOLOGY
fascicolo: 4, volume: 112, anno: 2001,
pagine: 674 - 682
SICI:
1388-2457(200104)112:4<674:THBPIP>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOVASCULAR AUTONOMIC DYSFUNCTION; MYOCARDIAL-INFARCTION; PERCEPTION; TOPOGRAPHY; THRESHOLD; ISCHEMIA; MELLITUS; PATHWAYS; ANGINA; PAIN;
Keywords:
diabetic neuropathy; evoked potential; autonomic nervous system; heartbeat perception; subjective symptoms;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Schandry, R Univ Munich, Inst Psychol, Leopoldstr 13, D-80802 Munich, Germany Univ Munich Leopoldstr 13 Munich Germany D-80802 ich, Germany
Citazione:
C. Leopold e R. Schandry, "The heartbeat-evoked brain potential in patients suffering from diabetic neuropathy and in healthy control persons", CLIN NEU, 112(4), 2001, pp. 674-682

Abstract

Objectives: Neurotransmission from the heart to the brain results in a heartbeat evoked potential (HEP). This potential appears as a positive waveform ranging from 250 to 600 ms after the onset of ventricular contraction. Only limited information exists as to what extent the HEP is sensitive to a dysfunction in cardio-afferent pathways. Thus. the HEP was studied in patients with autonomic diabetic neuropathy. Methods: Twenty-five patients and a healthy control group of equal size participated The HEP was obtained as the average over 1200 EEG sweeps (18 channels) sampled contingent upon the onset of ventricular contraction. A heartbeat attention task and a distraction task were employed. Patients answered a questionnaire pertaining to the frequency of subjective symptoms related to diabetic neuropathy. Results: The HEP amplitude at frontal, central and temporal locations was significantly diminished in patients in the latency range of 280-330 ms. A significant correlation was found between the questionnaire score of subjective autonomic symptoms and the reduction in the HEP. Conclusions: We conclude that the HEP is sensitive to a comparably moderate abnormality in nerve function. Furthermore, we assume that the processingof subjective symptoms of the disease and the generation of the HEP share some common neuronal pathways. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:25:00