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Titolo:
A medial to lateral shift in pre-movement cortical activity in hemi-Parkinson's disease
Autore:
Cunnington, R; Lalouschek, W; Dirnberger, G; Walla, P; Lindinger, G; Asenbaum, S; Brucke, T; Lang, W;
Indirizzi:
Univ Vienna, Dept Neurol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 a, Dept Neurol, A-1090 Vienna, Austria Univ Vienna, Dept Nucl Med, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 Dept Nucl Med, A-1090 Vienna, Austria Monash Univ, Dept Psychol, Clayton, Vic 3168, Australia Monash Univ Clayton Vic Australia 3168 chol, Clayton, Vic 3168, Australia
Titolo Testata:
CLINICAL NEUROPHYSIOLOGY
fascicolo: 4, volume: 112, anno: 2001,
pagine: 608 - 618
SICI:
1388-2457(200104)112:4<608:AMTLSI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPPLEMENTARY MOTOR AREA; POSITRON EMISSION TOMOGRAPHY; CONTINGENT NEGATIVE-VARIATION; FRONTAL-CORTEX; NEURONAL-ACTIVITY; RHESUS-MONKEYS; EXTERNAL CUES; BASAL GANGLIA; PREMOTOR; ACTIVATION;
Keywords:
hemi-Parkinson's disease; contingent negative variation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Lang, W Univ Vienna, Dept Neurol, Wahringer Gurtel 18-20, A-1090 Vienna, Austria Univ Vienna Wahringer Gurtel 18-20 Vienna Austria A-1090 Austria
Citazione:
R. Cunnington et al., "A medial to lateral shift in pre-movement cortical activity in hemi-Parkinson's disease", CLIN NEU, 112(4), 2001, pp. 608-618

Abstract

Objective: Recent evidence suggests that cortical activity associated withvoluntary movement is relatively shifted from medial to lateral premotor areas in Parkinson's disease. This shift occurs bilaterally even for unilateral responses. It is not clear whether the shift in processing reflects an overall change in movement strategy, thereby involving alternate cortical areas, or reflects a compensatory change whereby, given the appropriate conditions, less impaired cortical areas are able to provide a similar functionin compensation for those areas which are more impaired. This issue was examined in patients with hemi-Parkinson's disease, in whom basal ganglia impairment is most pronounced in one hemisphere. Methods: Fourteen patients with hemi-Parkinson's disease and 15 age-matched control subjects performed a Go/NoGo finger movement task and the contingent negative variation (CNV) was recorded from 21 scalp positions. Results and conclusions: Maximal CNV amplitudes were found over central medial regions for control subjects, but were shifted more frontally for Parkinson's disease patients, reduced in amplitude over the midline and lateralized towards the side ipsilateral to the greatest basal ganglia impairment. This shift in cortical activity from medial to lateral areas in Parkinson's disease patients appears to reflect a compensatory mechanism operating predominantly on the side of greatest basal ganglia impairment. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 23:16:05