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Titolo:
Impairment of motor cortex activation and deactivation in Parkinson's disease
Autore:
Chen, R; Kumar, S; Garg, RR; Lang, AE;
Indirizzi:
Univ Toronto, Hlth Network, Div Neurol, Toronto, ON, Canada Univ Toronto Toronto ON Canada Network, Div Neurol, Toronto, ON, Canada Univ Toronto, Hlth Network, Toronto Western Res Inst, Toronto, ON, Canada Univ Toronto Toronto ON Canada nto Western Res Inst, Toronto, ON, Canada
Titolo Testata:
CLINICAL NEUROPHYSIOLOGY
fascicolo: 4, volume: 112, anno: 2001,
pagine: 600 - 607
SICI:
1388-2457(200104)112:4<600:IOMCAA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRANIAL MAGNETIC STIMULATION; CHOICE REACTION-TIME; MOVEMENT-RELATED POTENTIALS; SELF-PACED MOVEMENTS; CORTICOSPINAL EXCITABILITY; BETA-SYNCHRONIZATION; ADVANCE INFORMATION; VOLUNTARY MOVEMENT; HUMAN BRAIN; BRADYKINESIA;
Keywords:
Parkinson's disease; motor cortex; bradykinesia; magnetic stimulation; voluntary movement; reaction time;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Chen, R Toronto Western Hosp, EC8-025,399 Bathurst St, Toronto, ON M5T 2S8, Canada Toronto Western Hosp EC8-025,399 Bathurst St Toronto ON Canada M5T2S8
Citazione:
R. Chen et al., "Impairment of motor cortex activation and deactivation in Parkinson's disease", CLIN NEU, 112(4), 2001, pp. 600-607

Abstract

Objectives: To examine the time course of corticospinal excitability before and after voluntary movement in Parkinson's disease (PD). Methods: We studied 9 mild PD patients at least 12 h off medications and 11 healthy volunteers in a simple reaction time (RT) paradigm. Suprathreshold transcranial magnetic stimulation was delivered to the left motor cortex at intervals covering the periods before and after movement. Results: PD patients (284 +/- 90 ms) and normal subjects (282 +/- 56 ms) had similar median RT. The time courses of both the premovement increase andthe postmovement decrease in corticospinal excitability were significantlydifferent between PD patients and normal subjects. The increase in motor-evoked potential (MEP) amplitudes began earlier for PD patients (200 ms before electromyographic (EMG) onset) than for normal subjects (150 ms before EMG onset), but the rate of increase was slower in PD patients than controls. After EMG offset, MEP amplitudes were increased for about 150 ms in normal subjects, but in PD patients this period was prolonged to about 350 ms. Conclusions: Impairment of motor cortex activation and deactivation is an early feature of PD and may be a physiological correlate of bradykinesia. The normal RT in our patients may be related to the earlier occurrence of the premovement increase in corticospinal excitability compensating for the slower rate of rise. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 04/04/20 alle ore 02:37:15