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Titolo:
Cardiac troponin and beta-type myosin heavy chain concentrations in patients with polymyositis or dermatomyositis
Autore:
Erlacher, P; Lercher, A; Falkensammer, J; Nassonov, EL; Samsonov, MI; Shtutman, VZ; Puschendorf, B; Mair, J;
Indirizzi:
Innsbruck Univ, Innere Med Klin, Klin Abt Kardiol, Dept Internal Med,Div Cardiol, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020rdiol, A-6020 Innsbruck, Austria Innsbruck Univ, Dept Med Chem & Biochem, Div Clin Biochem, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 ochem, A-6020 Innsbruck, Austria Cardiovasc Res Ctr, Moscow, Russia Cardiovasc Res Ctr Moscow RussiaCardiovasc Res Ctr, Moscow, Russia
Titolo Testata:
CLINICA CHIMICA ACTA
fascicolo: 1-2, volume: 306, anno: 2001,
pagine: 27 - 33
SICI:
0009-8981(200104)306:1-2<27:CTABMH>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; SKELETAL-MUSCLE DISORDERS; AMINO-ACID SEQUENCE; CREATINE-KINASE; IMMUNOTURBIDIMETRIC ASSAY; MULTICENTER EVALUATION; T ISOFORM; SERUM; MYOGLOBIN; DIAGNOSIS;
Keywords:
polymyositis; dermatomyositis; creatine kinase isoenzyme MB; cardiac troponin I; cardiac troponin T; myoglobin; myosin heavy chain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Mair, J Innsbruck Univ, Innere Med Klin, Klin Abt Kardiol, Dept Internal Med,Div Cardiol, Anichstr 35, A-6020 Innsbruck, Austria Innsbruck Univ Anichstr 35 Innsbruck Austria A-6020 ruck, Austria
Citazione:
P. Erlacher et al., "Cardiac troponin and beta-type myosin heavy chain concentrations in patients with polymyositis or dermatomyositis", CLIN CHIM A, 306(1-2), 2001, pp. 27-33

Abstract

Cardiac troponin T (cTnT), cardiac troponin I(cTnI), myosin heavy chains (MHC), myoglobin, creatine kinase (CK), and creatine kinase isoenzyme MB (CKMB), were measured in blood samples from 39 polymyositis (PM) or dermatomyositis (DM) patients without clinical evidence for cardiac involvement to evaluate their clinical usefulness in this patient population. MHC, myoglobin, and CKMB were frequently elevated and correlated with each other and withdisease severity. Undetectable cTnI in all but one patient indicated that MHC was released from skeletal muscle, thereby providing the first laboratory evidence of frequent slow-twitch muscle fibre-necrosis in patients with PM or DM. CKMB was elevated in 51%, cTnT in 41%, and cTnI in only 2.5% of patients, cTnI did not correlate with other markers or with disease severityscores. The close correlations found between cTnT and skeletal muscle damage markers and the relationship between cTnT with disease severity without clinical evidence for myocardial damage suggest a release of cTnT from skeletal muscle. The relationship of cTnT with disease severity indicates a possible role of the marker for risk stratification. However, the prognostic values of cardiac troponins and other muscle damage markers in PM/DM patients remain to be compared in prospective outcome trials. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 29/10/20 alle ore 20:27:37