Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Cardiovascular status of carriers of the apolipoprotein A-I-Milano mutant - The Limone sul Garda study
Autore:
Sirtori, CR; Calabresi, L; Franceschini, G; Baldassarre, D; Amato, M; Johansson, J; Salvetti, M; Monteduro, C; Zulli, R; Muiesan, ML; Agabiti-Rosei, E;
Indirizzi:
Univ Milan, Inst Pharmacol Sci, Ctr E Grossi Paoletti, I-20133 Milan, Italy Univ Milan Milan Italy I-20133 r E Grossi Paoletti, I-20133 Milan, Italy Univ Brescia, Cattedra Semeiot & Metodol Med, Brescia, Italy Univ BresciaBrescia Italy ttedra Semeiot & Metodol Med, Brescia, Italy Esper Therapeut Inc, Ann Arbor, MI USA Esper Therapeut Inc Ann Arbor MI USA er Therapeut Inc, Ann Arbor, MI USA
Titolo Testata:
CIRCULATION
fascicolo: 15, volume: 103, anno: 2001,
pagine: 1949 - 1954
SICI:
0009-7322(20010417)103:15<1949:CSOCOT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENSITY-LIPOPROTEIN CHOLESTEROL; INTIMA-MEDIA THICKNESS; MIDDLE-AGED MEN; RISK-FACTORS; IMILANO APOPROTEIN; LDL CHOLESTEROL; ATHEROSCLEROSIS; DISEASE; DIMER; PREVENTION;
Keywords:
lipoproteins; apolipoproteins; carotid arteries; intima-media thickening; heart diseases;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Sirtori, CR Univ Milan, Inst Pharmacol Sci, Ctr E Grossi Paoletti, Via Balzaretti 9, I-20133 Milan, Italy Univ Milan Via Balzaretti 9 Milan Italy I-20133 Milan, Italy
Citazione:
C.R. Sirtori et al., "Cardiovascular status of carriers of the apolipoprotein A-I-Milano mutant - The Limone sul Garda study", CIRCULATION, 103(15), 2001, pp. 1949-1954

Abstract

Background-Carriers of the apolipoprotein A-I-Milano (apoA-I-M) mutant present with very low plasma HDL cholesterol and moderate hypertriglyceridemia, apparently not leading to premature coronary heart disease. The objectiveof this study was to establish whether this high-risk lipid/lipoprotein profile is associated with structural changes in the carotid arteries and heart, indicative of preclinical atherosclerosis. Methods and Results-Twenty-one A-I-M carriers were compared with age- and sex-matched control subjects from the same kindred and with 2 series of matched subjects with primary hypoalphalipoproteinemia (HA). Structural changes in the carotid arteries were defined as the intima-media thickness (IMT) measured by B-mode ultrasound. HA subjects, both recruited among patients attending our Lipid Clinic and blood donors, showed significant thickening of the carotids (average IMT, 0.86 +/-0.25 and 0.88 +/-0.29 mm, respectively) compared with control subjects (average IMT, 0.64 +/-0.12 mm); the apoA-I-M carriers instead showed normal arterial thickness (average IMT, 0.63 +/-0.10 mm). Moreover, a significantly higher prevalence of atherosclerotic plaques was found in patients and blood donors with HA (both 57%) compared with apoA-I-M carriers (33%) and control subjects (21%). Echocardiographic findings and maximal treadmill ECG did not differ significantly between apoA-I-M carriers and control subjects, apart from a slight increase in left ventricular end-diastolic dimension in the carriers,Conclusions-Despite severe HA, carriers of the apoA-I-M mutant do not showstructural changes in the arteries and heart, in contrast to HA subjects, who are characterized by a marked increase in carotid IMT and increased prevalence of atherosclerotic plaques.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 01:34:09