Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Factor V Leiden mutation in one family of Chinese origin
Autore:
Wu, JS; Gu, JM; Xu, J; Wang, J; Sun, ZM; Smirnov, MD; Morrissey, JH; Esmon, N;
Indirizzi:
Anhui Prov Hosp, Hefei 230001, Peoples R China Anhui Prov Hosp Hefei Peoples R China 230001 fei 230001, Peoples R China Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA Oklahoma Med Res Fdn Oklahoma City OK USA 73104 lahoma City, OK 73104 USA
Titolo Testata:
CHINESE MEDICAL JOURNAL
fascicolo: 4, volume: 114, anno: 2001,
pagine: 379 - 381
SICI:
0366-6999(200104)114:4<379:FVLMIO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED PROTEIN-C; RESISTANCE;
Keywords:
APC resistance; FV Leiden gene mutation; heterozygous;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
6
Recensione:
Indirizzi per estratti:
Indirizzo: Wu, JS Anhui Prov Hosp, Hefei 230001, Peoples R China Anhui Prov Hosp Hefei Peoples R China 230001 001, Peoples R China
Citazione:
J.S. Wu et al., "Factor V Leiden mutation in one family of Chinese origin", CHIN MED J, 114(4), 2001, pp. 379-381

Abstract

Objective To investigate the factor V Leiden mutation associated with activated protein C resistance (APCR) in Chinese. Methods Thirty "normal" individuals and twenty patients with thrombotic disease from Chinese Han Nationality were studied with APTT +/- APC, PCR followed by MnLI restriction enzyme analysis, PCR based direct sequence-specific primers (PCR-SSP) and DNA sequence analysis. Results In one healthy control, the activated protein C (APC) sensitivity ratio (SR) was found to be significantly lower (0.8) than that in other normal control (> 2.0). This individual was identified to be heterozygous for FV Leiden mutaiton (Arg506-Gln). His grand-uncle, father, brother and son were also identified to be heterozygous for FV Leiden. The APC resistance was found in 3 other cases of thrombotice diseases, but with no FV Leiden mutation. Conclusion This is the first four generations family case of FV Leiden mutation associated with APCR reported within Chinese ethnic population. It isnote-worthy that more FV Leiden or whether other gene defects may be associated with APC resistance and acquired APCR causing thrombosis in Chinese population.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 03:28:33