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Titolo:
Intravenous thrombolysis in proximal middle cerebral artery occlusion
Autore:
Schneweis, S; Grond, M; Neveling, M; Schmulling, S; Rudolf, J; Heiss, WD;
Indirizzi:
Univ Cologne, Neurol Klin, D-50924 Cologne, Germany Univ Cologne CologneGermany D-50924 urol Klin, D-50924 Cologne, Germany
Titolo Testata:
CEREBROVASCULAR DISEASES
fascicolo: 3, volume: 11, anno: 2001,
pagine: 212 - 215
SICI:
1015-9770(2001)11:3<212:ITIPMC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE ISCHEMIC STROKE; COMPUTED-TOMOGRAPHY; EARLY CT; PROUROKINASE; PROACT; TRIAL;
Keywords:
thrombolysis; middle cerebral artery occlusion; stroke, acute;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Heiss, WD Univ Cologne, Neurol Klin, Joseph Stelzmann Str 9, D-50924 Cologne, Germany Univ Cologne Joseph Stelzmann Str 9 Cologne Germany D-50924 any
Citazione:
S. Schneweis et al., "Intravenous thrombolysis in proximal middle cerebral artery occlusion", CEREB DIS, 11(3), 2001, pp. 212-215

Abstract

Subgroup analyses of data from an open-label study of intravenous recombinant tissue plasminogen activator (rt-PA) administered to stroke patients were performed. Clinical outcome and incidence of intracranial hemorrhage were evaluated in 20 patients diagnosed by transcranial Doppler ultrasound as having proximal middle cerebral artery (MCA) occlusion. Additionally early infarct signs and size of final infarction were assessed. A favorable outcome (mRS 0-2) was seen in 30% of all patients. The incidence of symptomatic intracranial hematoma (10%) in patients with proximal MCA occlusion was higher than the overall hemorrhage rate of intravenous rt-PA treatment, but comparable to the data on intra-arterial thrombolysis in this stroke subgroup. All patients except 1 developed ischemic infarction in the MCA territory. Intravenous rt-PA treatment within 3 h may also be effective in patients with proximal MCA occlusion. The risk of intracerebral hematoma does not seem to be greater than in intra-arterial thrombolysis. Copyright (C) 2001 S.Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 02:44:48