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Titolo:
Cerebral vein and dural sinus thrombosis in Portugal: 1980-1998
Autore:
Ferro, JM; Correia, M; Pontes, C; Baptista, MV; Pita, F;
Indirizzi:
Hosp Santa Maria, Ctr Estudos Egas Moinz, Dept Neurol, P-1649035 Lisbon, Portugal Hosp Santa Maria Lisbon Portugal P-1649035 l, P-1649035 Lisbon, Portugal
Titolo Testata:
CEREBROVASCULAR DISEASES
fascicolo: 3, volume: 11, anno: 2001,
pagine: 177 - 182
SICI:
1015-9770(2001)11:3<177:CVADST>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENOUS THROMBOSIS; INTRACRANIAL HYPERTENSION; HEPARIN TREATMENT; PROTHROMBIN-GENE; PREGNANCY; PUERPERIUM; MUTATION; ADULTS;
Keywords:
cerebral vein; dural sinus, thrombosis; anticoagulation; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Ferro, JM Hosp Santa Maria, Ctr Estudos Egas Moinz, Dept Neurol, P-1649035Lisbon, Portugal Hosp Santa Maria Lisbon Portugal P-1649035 35 Lisbon, Portugal
Citazione:
J.M. Ferro et al., "Cerebral vein and dural sinus thrombosis in Portugal: 1980-1998", CEREB DIS, 11(3), 2001, pp. 177-182

Abstract

There is insufficient information on the prognosis and safety of anticoagulation in acute cerebral vein and dural sinus thrombosis (CVDST). To describe the clinical aspects and medical management of CVDST in Portuguese hospitals, to evaluate the safety of anticoagulation in this setting, and to identify subgroups of CVDST patients with different prognoses, we registered symptomatic CVDST patients admitted to Portuguese hospitals since 1980, Cases were collected from file review up to 6/95 and from consecutively admitted patients from 6/95 to 6/98, One hundred and forty-two patients were included from 20 centers (51 retrospectively and 91 prospectively). One hundred and twelve patients (79%) were anticoagulated. There were only 6 new intracranial hemorrhages (4 in anticoagulated patients) and 2 systemic hemorrhages, Nine (6%) patients died. At discharge, 96 [68%), had recovered completely and only 6 (4%) were dependent (Rankin greater than or equal to 3). Significant multivariate predictors of death/dependency were central nervous system infection as a predisposing cause (odds ratio, OR = 15.4; 95% confidence interval Cl = 111-1.1), encephalopathy on admission (OR = 5.2; 95% Cl = 18.7-1.5) and hemorrhage on admission CT/MR (OR = 3.6; 95% Cl = 12.9-1). Significant predictors of complete recovery were no encephalopathy on admission (OR = 5; 95% Cl = 12.5-2.1), age <45 years (OR = 3.8; 95% Cl = 9.2-1.6) and anticoagulation (OR = 3.8; 95% Cl = 9.6-1.5). It is possible to identifyCVDST patients with potential bad or good prognosis in the acute phase. Anticoagulation was safe and a predictor of complete recovery in acute CVDST,Copyright <(c)> 2001 S. KargerAG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 00:34:20