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Titolo:
Early diagnosis of hemorrhagic transformation: Diffusion/perfusion-weighted MRI versus CT scan
Autore:
Nighoghossian, N; Hermier, M; Berthezene, Y; Wiart, M; Derex, L; Honnorat, J; Trouillas, P; Turjman, F; Froment, JC;
Indirizzi:
CNRS, UMR 5515, Cardiovasc Dis & Ataxia Res Ctr, Lyon, France CNRS Lyon France MR 5515, Cardiovasc Dis & Ataxia Res Ctr, Lyon, France CNRS, UMR 5515, Dept Radiol, Lyon, France CNRS Lyon FranceCNRS, UMR 5515, Dept Radiol, Lyon, France CNRS, UMR 5515, Creatis, Lyon, France CNRS Lyon FranceCNRS, UMR 5515, Creatis, Lyon, France
Titolo Testata:
CEREBROVASCULAR DISEASES
fascicolo: 3, volume: 11, anno: 2001,
pagine: 151 - 156
SICI:
1015-9770(2001)11:3<151:EDOHTD>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE ISCHEMIC STROKE; TISSUE-PLASMINOGEN-ACTIVATOR; INTRACEREBRAL HEMORRHAGE; THROMBOLYTIC THERAPY; CEREBRAL INFARCTION; BRAIN; APPEARANCE; ECASS; ONSET;
Keywords:
magnetic resonance imaging; acute ischemic stroke; early hemorrhagic transformation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Nighoghossian, N Hop Neurol, Serv Neurol B, 59 Pinel Bvd, F-69003 Lyon, France Hop Neurol 59 Pinel Bvd Lyon France F-69003 Lyon, France
Citazione:
N. Nighoghossian et al., "Early diagnosis of hemorrhagic transformation: Diffusion/perfusion-weighted MRI versus CT scan", CEREB DIS, 11(3), 2001, pp. 151-156

Abstract

Standard magnetic resonance imaging (MRI) techniques failed to image adequately acute hemorrhagic transformation (HT), Therefore, computed tomography(CT) is still needed to exclude intracerebral hemorrhage. New MRI techniques such as diffusion- and perfusion-weighted imaging (DWI and PWI) may improve the early detection of HT. The utility of this approach requires a direct comparison of the sensitivity of CT with these MRI techniques. Methods: Nine patients experienced an acute carotid artery territory ischemic strokediagnosed on a first CT performed 3.8 +/- 2h after the onset of stroke. They underwent a second CT 12 +/- 4 h after the onset of stroke, followed 35 /- 10 min later by an MRI protocol including: (1) an axial isotropic DWI SE echo-planar imaging IEP)) sequence; (2) time of flight MR angiography (TOF MRA); (3) PWI with an axial T-2*-weighted gradient echo EPl sequence using 20 mi gadolinium contrast agent (Gd-DTPA); HT was characterized on DWI SEEPI as a heterogeneous area of signal loss within the ischemic area; (4) at day 7, CT was also performed in all patients who had an early suspicion of bleeding according to MRI. Results: An HT was detected exclusively with CT in 1 out of 9 patients, while an MRI pattern of HT was found in 6 out of 9 patients. In 5 of these 6 patients, the CT scan did not show an obvious pattern of HT. Day 7 CT confirmed HT in all patients who had early suspicionof bleeding according to DWI criteria. Conclusion: This study suggests that new MRI techniques may allow an early detection of HT, thus improving themanagement of stroke. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 09:55:14