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Titolo:
Qualitative and quantitative estimates of apoptosis from birth to senescence in the rat brain
Autore:
White, LD; Barone, S;
Indirizzi:
US EPA, Cellular & Mol Toxciol Branch, Div Neurotoxicol, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA US EPA Res Triangle Pk NC USA 27711 es Lab, Res Triangle Pk, NC 27711 USA
Titolo Testata:
CELL DEATH AND DIFFERENTIATION
fascicolo: 4, volume: 8, anno: 2001,
pagine: 345 - 356
SICI:
1350-9047(200104)8:4<345:QAQEOA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; CEREBELLAR GRANULE NEURONS; CENTRAL-NERVOUS-SYSTEM; DNA FRAGMENTATION; CEREBRAL-CORTEX; GROWTH-FACTOR; POSTNATAL-DEVELOPMENT; ALZHEIMERS-DISEASE; UNDERGO APOPTOSIS; LAYER NEURONS;
Keywords:
apoptosis; programmed cell death; neocortex; cerebellum; brainstem; hippocampus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Barone, S US EPA, Cellular & Mol Toxciol Branch, Div Neurotoxicol, Natl Hlth & Environm Effects Res Lab, Mail Drop 74B, Res Triangle Pk, NC 27711 USAUS EPA Mail Drop 74B Res Triangle Pk NC USA 27711 , NC 27711 USA
Citazione:
L.D. White e S. Barone, "Qualitative and quantitative estimates of apoptosis from birth to senescence in the rat brain", CELL DEAT D, 8(4), 2001, pp. 345-356

Abstract

Apoptosis is crucial for proper development of the CNS, wherein a significant percentage of all central neurons produced during early ontogeny die byapoptosis. To characterize the pattern of developmental programmed cell death, we assayed rat brainstem, neocortex, hippocampus, and cerebellum from birth through senescence. Quantitatively, using an ELISA for oligonucleosomal DNA fragments, we demonstrated that PND1 brainstem, neocortex, and hippocampus have the highest levels of fragmented DNA compared to older ages. Cerebellum displayed a large peak at PND10 and a smaller peak at PND21, Low levels were observed throughout adulthood and into senescence, which was corroborated qualitatively by agarose gel and TUNEL data. These data provide atemporal and regional baseline for further studies of the effects of perturbations of cell death during neural development. Quantitative and qualitative changes in these regional profiles of apoptosis due to environmental insults during early ontogeny may alter neuron number and function later in life.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:55:42