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Titolo:
Prognostic significance of combined conventional and immunocytochemical cytology for peritoneal washings in endometrial carcinoma
Autore:
Luo, ML; Sakuragi, N; Shimizu, M; Seino, K; Okamoto, K; Kaneuchi, M; Ebina, Y; Okuyama, K; Fujino, T; Sagawa, T; Fujimoto, S;
Indirizzi:
Hokkaido Univ, Sch Med, Dept Obstet & Gynecol, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 oro, Hokkaido 0608638, Japan Hokkaido Univ Hosp, Dept Surg Pathol, Sapporo, Hokkaido 060, Japan Hokkaido Univ Hosp Sapporo Hokkaido Japan 060 apporo, Hokkaido 060, Japan Hokkaido Canc Soc, Ctr Clin Cytol, Sapporo, Hokkaido, Japan Hokkaido Canc Soc Sapporo Hokkaido Japan Cytol, Sapporo, Hokkaido, Japan
Titolo Testata:
CANCER CYTOPATHOLOGY
fascicolo: 2, volume: 93, anno: 2001,
pagine: 115 - 123
SICI:
0008-543X(20010425)93:2<115:PSOCCA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
BODY CAVITY FLUIDS; CLINICAL STAGE-I; ADENOCARCINOMA; P53; EXPRESSION; INDICATOR; DISEASE; CANCER; CELLS;
Keywords:
immunocytochemistry; peritoneal cytology; MOC-31; p53; endometrial carcinoma; survival;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Sakuragi, N Hokkaido Univ, Sch Med, Dept Obstet & Gynecol, N15,W7, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ N15,W7 Sapporo Hokkaido Japan 0608638 638, Japan
Citazione:
M.L. Luo et al., "Prognostic significance of combined conventional and immunocytochemical cytology for peritoneal washings in endometrial carcinoma", CANC CYTOP, 93(2), 2001, pp. 115-123

Abstract

BACKGROUND. Noncancerous cells simulating adenocarcinoma cells may interfere with the analysis of peritoneal cytology (PC) in patients with endometrial carcinoma. Immunocytochemistry (ICC) may improve the diagnosis of PC. METHODS, PC slides from 115 patients with endometrial carcinoma were reviewed. Suspicious or positive cell clusters were recovered with a cell transfer method and were subjected to ICC for MOC-31, cytokeratin 5/6, and p53. Conventional Papanicolaou staining and ICC results were compared directly onthe same cells. RESULTS. By combined conventional and immunocytochemical PC (CONV-ICC-PC),cytodiagnosis was positive in 18 of 115 patients (15.7%) and suspicious in3 of 115 patients (2.6%). According to a multivariate Cox regression analysis of patients with tumors confined to the uterus that included grade, myometrial invasion, cervical involvement, and CONV-ICC-PC, only CONV-ICC-PC was an independent prognostic factor (P < 0.05). A multivariate analysis forall of the patients studied that compared CONV-ICC-PC with staging variables revealed that only peritoneal metastasis (P < 0.0001) and lymph node metastasis (P < 0.01) were independent prognostic factors. When peritoneal metastases were excluded, CONV-ICC-PC (P < 0.01) and lymph node metastasis (P < 0.0025) were the independent prognostic factors. By cell transfer and p53immunostaining in samples from 14 patients with malignant cells in their peritoneal washings, no deaths occurred among 5 patients with negative p53, whereas 5 of 9 patients with positive p53 died of disease at the time of data analysis. CONCLUSIONS, MOC-31 immunostaining improves the diagnosis of PC in endometrial carcinoma. Positive PC is an important prognostic factor for patients with endometrial carcinoma confined to the uterus. The p53 positive cells in PC have possible prognostic significance. Cancer (Cancer Cytopathol) 2001;93:115-123, (C) 2001 American Cancer Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:32:16