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Titolo:
The inhibitory effect of serotonin on the spontaneous discharge of suprachiasmatic neurons in hypothalamic slice is mediated by 5-HT7 receptor
Autore:
Yu, GD; Liu, YL; Jiang, XH; Guo, SY; Zhang, HQ; Yin, QZ; Hisamitsu, T;
Indirizzi:
Soochow Univ, Sch Med, Neurobiol Lab, Suzhou 215007, Peoples R China Soochow Univ Suzhou Peoples R China 215007 uzhou 215007, Peoples R China Showa Univ, Sch Med, Dept Physiol, Shinjuku Ku, Tokyo, Japan Showa Univ Tokyo Japan Sch Med, Dept Physiol, Shinjuku Ku, Tokyo, Japan
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 4, volume: 54, anno: 2001,
pagine: 395 - 398
SICI:
0361-9230(20010301)54:4<395:TIEOSO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CIRCADIAN-RHYTHMS; RAT; NUCLEUS; INVITRO;
Keywords:
suprachiasmatic nucleus; brain slice; 5-hydroxytryptamine; 8-OH-DPAT; ritanserin; pindolol; ketanserin; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Yu, GD Soochow Univ, Sch Med, Neurobiol Lab, 48 Renmin Rd, Suzhou 215007, PeoplesR China Soochow Univ 48 Renmin Rd Suzhou Peoples R China 215007 lesR China
Citazione:
G.D. Yu et al., "The inhibitory effect of serotonin on the spontaneous discharge of suprachiasmatic neurons in hypothalamic slice is mediated by 5-HT7 receptor", BRAIN RES B, 54(4), 2001, pp. 395-398

Abstract

The effects of serotonin (5-HT) receptor agonists and antagonists on the spontaneous discharge of suprachiasmatic nucleus (SCN) neurons were investigated using rat hypothalamic slice. It was found that: (1) the SCN neurons showed a persistent rhythm in the spontaneous discharge rate, which was higher during the light phase than during the dark phase; (2) the effects of 5-HT on SCN neurons was inhibitory in nature and the sensitivity of SCN neurons to 5-HT during the light phase was lower than that during the dark phase; (3) both 5-HT and 5-HT1/7 receptor agonist, (+/-)-8-hydroxy-2-(DL-N-propylamino) tetralin hydrobromide, could inhibit the spontaneous discharge of SCN neurons. This inhibitory effect could be blocked by 5-HT27 receptor antagonist ritanserin and putative 5-HT7 receptor antagonists clozapine, but neither by selective 5-HT2 receptor antagonist ketanserin, nor by 5-HT1 receptor antagonist pindolol, It was suggested that the inhibitory effect of 5-HT on the spontaneous discharge of SCN neurons in rat hypothalamic slice is mediated by 5-HT7 receptor subtype, (C) 2001 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 18:59:22