Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Neurochemical phenotype of sympathetic nervous system outflow from brain to white fat
Autore:
Shi, HF; Bartness, TJ;
Indirizzi:
Georgia State Univ, Dept Biol, Neurobiol & Behav Program, Atlanta, GA 30303 USA Georgia State Univ Atlanta GA USA 30303 av Program, Atlanta, GA 30303 USA
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 4, volume: 54, anno: 2001,
pagine: 375 - 385
SICI:
0361-9230(20010301)54:4<375:NPOSNS>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
BROWN ADIPOSE-TISSUE; PSEUDORABIES VIRUS; ACID MOBILIZATION; SPINAL-CORD; RAT; NEURONS; HYPOTHALAMUS; NUCLEUS;
Keywords:
Siberian hamsters; tyrosine hydroxylase; dopamine beta-hydroxylase; arginine vasopressin; oxytocin; pseudorabies virus; tract tracing; suprachiasmatic nucleus; paraventricular nucleus; brainstem; lipolysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Bartness, TJ Georgia State Univ, Dept Biol, Neurobiol & Behav Program, 24 Peachtree CtrRd NE, Atlanta, GA 30303 USA Georgia State Univ 24 Peachtree Ctr Rd NE Atlanta GA USA 30303
Citazione:
H.F. Shi e T.J. Bartness, "Neurochemical phenotype of sympathetic nervous system outflow from brain to white fat", BRAIN RES B, 54(4), 2001, pp. 375-385

Abstract

The sympathetic innervation of white adipose tissue (WAT) appears to be a dominant mechanism triggering lipolysis. The purpose of this study was to determine the neurochemical phenotype of neurons comprising the sympathetic outflow from brain to WAT. This was accomplished by injecting Siberian hamster WAT with a viral retrograde transneuronal tract tracer, the pseudorabies virus (PRV), in combination with immunocytochemical characterization of several neurotransmitters or their synthetic enzymes in the brain. Catecholaminergic (tyrosine hydroxylase [TH] and dopamine-beta -hydroxylase [DBH] immunoreactivity) and peptidergic (arginine vasopressin [AVP] and oxytocin [OXY] immunoreactivity) neurons were part of this outflow, but the percentageof double-labeled cells was small, consistent with previous studies. Brainstem PRV + TH-or PRV + DBH-labeled cells were in previously identified noradrenergic areas (A5, A6, and subcoeruleus, rostroventrolateral medulla [RVL], some reticular nuclei). Forebrain double labeling was greatest in the paraventricular (TH, AVP, OXY) and suprachiasmatic (AVP) nuclei, both implicated in the central control of lipolysis. Differences between the PRV doublelabeling reported here for WAT versus that of other sympathetic peripheraltargets were PRV + DBH in A5 and RVL, and PRV + TH in RVL and in the lateral paragigantocellular and lateral reticular nuclei. Collectively, these results begin to identify the neurochemical identity of the sympathetic outflow from brain to WAT. (C) 2001 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 07:15:20