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Titolo:
Ethanol reduces rCFB activation of left dorsolateral prefrontal cortex during a verbal fluency task
Autore:
Wendt, PE; Risberg, J;
Indirizzi:
Univ Lund, Dept Psychol, SE-22100 Lund, Sweden Univ Lund Lund Sweden SE-22100 Lund, Dept Psychol, SE-22100 Lund, Sweden Univ Lund, Dept Clin Neurosci, Sect Psychiat, SE-22100 Lund, Sweden Univ Lund Lund Sweden SE-22100 sci, Sect Psychiat, SE-22100 Lund, Sweden Univ Lund, Dept Psychol, SE-22100 Lund, Sweden Univ Lund Lund Sweden SE-22100 Lund, Dept Psychol, SE-22100 Lund, Sweden
Titolo Testata:
BRAIN AND LANGUAGE
fascicolo: 2, volume: 77, anno: 2001,
pagine: 197 - 215
SICI:
0093-934X(200105)77:2<197:ERRAOL>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; POSITRON-EMISSION TOMOGRAPHY; RESTING NORMAL SUBJECTS; HEMISPHERIC-ASYMMETRY; FRONTAL-LOBE; EVOKED-POTENTIALS; NEUROPSYCHOLOGICAL FUNCTION; TEMPORAL ORGANIZATION; INHALATION TECHNIQUE; GLUCOSE-METABOLISM;
Keywords:
regional cerebral blood flow; functional lateralization; ethanol; cortical asymmetry; verbal fluency; DLPFC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
90
Recensione:
Indirizzi per estratti:
Indirizzo: Risberg, J Univ Lund, Dept Psychol, POB 213, SE-22100 Lund, Sweden Univ Lund POB 213 Lund Sweden SE-22100 , SE-22100 Lund, Sweden
Citazione:
P.E. Wendt e J. Risberg, "Ethanol reduces rCFB activation of left dorsolateral prefrontal cortex during a verbal fluency task", BRAIN LANG, 77(2), 2001, pp. 197-215

Abstract

In a previous study in normal subjects (Wendt et al., 1994), using a reversing checkerboard as activation stimulus, we found that the coupling between local neuronal activity and regional cerebral blood flow was preserved following ethanol, and that a right-sided occipital activation response seen during sobriety became symmetrical during inebriation. In the present studywe investigated if ethanol has a detrimental effect also on the activationof the left dorsolateral prefrontal cortex found in normals during verbal fluency. Measurements of regional cerebral blood flow in 20 healthy, young,male, right-handed volunteers during rest and verbal fluency were made during sobriety and inebriation (0.06% blood alcohol concentration) with a I-week interval. We found a decrease in word production during inebriation. The normal activation within the frontotemporal part of the left dorsolateralprefrontal cortext was preserved during inebriation. The activation of this region seems thus to be robust to the effects of ethanol. During inebriation no activation response to the word fluency test was found in the anterior prefrontal part of the dorsolateral prefrontal cortex. This region is important for working, temporal, and short-term memory functions, processes that are affected by ethanol. Hemispheric functioning and specialization seem to be adversely affected by ethanol, regardless of which hemisphere is most involved while sober. (C) 2001 Academic Press.

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Documento generato il 03/04/20 alle ore 10:56:17