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Titolo:
Influence of CD34(+) marrow cell dose on outcome of HLA-identical sibling allogeneic bone marrow transplants in patients with chronic myeloid leukaemia
Autore:
Morariu-Zamfir, R; Rocha, V; Devergie, A; Socie, G; Ribaud, P; Esperou, H; Parquet, N; Guardiola, P; Dal Cortivo, L; Bittencourt, H; Garnier, F; Traineau, R; Marolleau, JP; Chevret, S; Gluckman, E;
Indirizzi:
Hop St Louis, Stem Cell Transplant Unit, F-75475 Paris 10, France Hop St Louis Paris France 10 l Transplant Unit, F-75475 Paris 10, France Hop St Louis, Lab Cellular Therapy, F-75475 Paris, France Hop St Louis Paris France F-75475 ellular Therapy, F-75475 Paris, France Hop St Louis, Dept Biostat, F-75475 Paris 10, France Hop St Louis Paris France 10 uis, Dept Biostat, F-75475 Paris 10, France
Titolo Testata:
BONE MARROW TRANSPLANTATION
fascicolo: 6, volume: 27, anno: 2001,
pagine: 575 - 580
SICI:
0268-3369(200103)27:6<575:IOCMCD>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD STEM-CELLS; VERSUS-HOST DISEASE; HEMATOLOGIC MALIGNANCIES; ENGRAFTMENT; GRAFT; SURVIVAL; LEUKEMIA; RECOVERY; DONORS;
Keywords:
CD34 cell dose; allogeneic bone marrow transplant; chronic myeloid leukaemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Gluckman, E Hop St Louis, Stem Cell Transplant Unit, 1 Ave Claude Vellefaux, F-75475 Paris 10, France Hop St Louis 1 Ave Claude Vellefaux Paris France 10 0, France
Citazione:
R. Morariu-Zamfir et al., "Influence of CD34(+) marrow cell dose on outcome of HLA-identical sibling allogeneic bone marrow transplants in patients with chronic myeloid leukaemia", BONE MAR TR, 27(6), 2001, pp. 575-580

Abstract

In order to study the influence of bone marrow CD34(+) cell dose on the outcome of allogeneic bone marrow transplantation (BMT), we analysed the results of BMT from HLA-identical siblings donors In 50 patients with chronic myeloid leukaemia (CML). The median numbers of nucleated cells (NC) and CD34(+) cells infused were 2.18 x 10(8)/kg (0.05-4.14 x 10(8)/kg) and 3.12 x 10(6)/kg (0.35-8.52 x 10(6)/kg), respectively. All patients engrafted, In univariate analysis, there was no correlation between the number of CD34(+) cells infused and the time to neutrophil recovery (P = 0.17), The Kaplan-Meier estimate of grade II-IV acute graft-versus-host disease (GVHD) at day 100was 53 +/- 14% and 2-year survival was 46 +/- 15%, A number of CD34(+) cells infused greater than the median was the main factor increasing survival (P = 0.0006) and decreasing 100 day transplant-related mortality (P = 0.009), Patient-, disease- and transplant-related characteristics were not statistically different among patients receiving more or less than the median number of CD34(+) cells, The rate of infectious deaths was significantly higher in patients receiving less than 3.12 x 10(6) CD34/kg (48% vs 16%, P = 0.01). In a multivariable analysis, two factors associated with increased risk of death were advanced disease status at transplant (HR: 2.5 (95% CI: 1.09-5.75), P = 0.03) and a lower number of marrow CD34(+) cells infused/kg (HR: 4.55 (95% CI: 1.87-10.90), P = 0.0008).

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Documento generato il 15/07/20 alle ore 08:09:09