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Titolo:
A pilot study of rapid lithium administration in the treatment of acute mania
Autore:
Keck, PE; Strakowski, SM; Hawkins, JM; Dunayevich, E; Tugrul, KC; Bennett, JA; McElroy, SL;
Indirizzi:
Univ Cincinnati, Coll Med, Dept Psychiat, Biol Psychiat Program, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 Program, Cincinnati, OH 45267 USA
Titolo Testata:
BIPOLAR DISORDERS
fascicolo: 2, volume: 3, anno: 2001,
pagine: 68 - 72
SICI:
1398-5647(200104)3:2<68:APSORL>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOSAGE REQUIREMENTS; BIPOLAR PATIENTS; CARBONATE; PREDICTION; DIVALPROEX; VALPROATE; PROGNOSTICATOR; CHLORPROMAZINE; DEPRESSION; LEVEL;
Keywords:
bipolar disorder; lithium; mania; rapid loading;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Keck, PE Univ Cincinnati, Coll Med, Dept Psychiat, Biol Psychiat Program, POB 670559,231 Bethesda Ave, Cincinnati, OH 45267 USA Univ Cincinnati POB 670559,231 Bethesda Ave Cincinnati OH USA 45267
Citazione:
P.E. Keck et al., "A pilot study of rapid lithium administration in the treatment of acute mania", BIPOL DIS, 3(2), 2001, pp. 68-72

Abstract

Objectives: The use of rapid lithium dosage administration, a strategy that could lead to rapid improvement in mania, has been largely unexamined. Inthis open-label, pilot, acute-treatment study, we sought to determine the safety and tolerability of lithium administered at 20 mg/kg/day. A secondary aim was to provide preliminary data regarding the efficacy of this strategy in ameliorating manic, depressive, and psychotic symptoms. Methods: Fifteen patients hospitalized with DSM-IV bipolar disorder, manicor mixed, and who provided written informed consent, received lithium 20 mg/kg/day for up to 10 days. Patients were evaluated for adverse effects daily. Lithium levels were obtained on days 2, 3, 4, 5, 7, and 10 or at study termination. Electrocardiograms (EKCs) were performed at baseline and on days 1-5, 7, and 10 or at study termination. Symptomatic improvement was assessed daily using the Young Mania Rating Scale, 24-item Hamilton Depression Rating Scale, and the Scale for Assessment of Positive Symptoms (SAPS). Results: Five of the 15 patients completed the 10-day study period. Two patients dropped out due to adverse events. Seven patients did not complete the inpatient trial because of improvement sufficient to allow hospital discharge. All patients achieved serum lithium concentrations greater than or equal to 0.6 mEq/L after 1 day of treatment; the mean +/- SD concentration on day 5 was 1.1 (+/- 0.1) mEq/L on day 5. There were significant reductionsfrom baseline to endpoint on all rating scales, except the SAPS bizarre behavior subscale. Conclusions: These pilot data suggest that lithium 20 mg/kg/day was well tolerated and that this strategy may produce rapid improvement in affective and psychotic symptoms. These impressions require confirmation in double-blind. randomized trials.

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Documento generato il 28/01/20 alle ore 14:49:16