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Titolo:
Novel inhibitors of Leishmanial dihydrofolate reductase
Autore:
Chowdhury, SF; Di Lucrezia, R; Guerrero, RH; Brun, R; Goodman, J; Ruiz-Perez, LM; Pacanowska, DG; Gilbert, IH;
Indirizzi:
Cardiff Univ, Welsh Sch Pharm, Cardiff CF10 3XF, S Glam, Wales Cardiff Univ Cardiff S Glam Wales CF10 3XF ardiff CF10 3XF, S Glam, Wales Inst Parasitol & Biomed, Granada 18001, Spain Inst Parasitol & Biomed Granada Spain 18001 Biomed, Granada 18001, Spain Swiss Trop Inst, CH-4002 Basel, Switzerland Swiss Trop Inst Basel Switzerland CH-4002 st, CH-4002 Basel, Switzerland Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England Univ Cambridge Cambridge England CB2 1EW hem, Cambridge CB2 1EW, England
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
fascicolo: 8, volume: 11, anno: 2001,
pagine: 977 - 980
SICI:
0960-894X(20010423)11:8<977:NIOLDR>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYMIDYLATE SYNTHASE; DESIGN; TRYPANOSOMES; DISCOVERY; FORMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Gilbert, IH Cardiff Univ, Welsh Sch Pharm, King Edward VII Ave, Cardiff CF10 3XF, S Glam, Wales Cardiff Univ King Edward VII Ave Cardiff S Glam WalesCF10 3XF
Citazione:
S.F. Chowdhury et al., "Novel inhibitors of Leishmanial dihydrofolate reductase", BIOORG MED, 11(8), 2001, pp. 977-980

Abstract

The program DOCK3.5 was used to search the Cambridge Structural Database for novel inhibitors of Leishmanial dihydrofolate reductase. A number of compounds were obtained and screened against the enzyme and against the intactparasite Leishmania donovani and the related organisms Trypanosoma brucei and Trypanosoma cruzi. The compounds screened showed weak activity in both the enzyme assays and the in vitro assays. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:25:39