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Titolo:
The muscarinic agonist xanomeline increases monoamine release and immediate early gene expression in the rat prefrontal cortex
Autore:
Perry, KW; Nisenbaum, LK; George, CA; Shannon, HE; Felder, CC; Bymaster, FP;
Indirizzi:
Eli Lilly & Co, Lilly Corp Ctr, Lilly Res Labs, Neurosci Res Div, Indianapolis, IN 46285 USA Eli Lilly & Co Indianapolis IN USA 46285 Div, Indianapolis, IN 46285 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 8, volume: 49, anno: 2001,
pagine: 716 - 725
SICI:
0006-3223(20010415)49:8<716:TMAXIM>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATYPICAL ANTIPSYCHOTIC-DRUGS; STRIATAL DOPAMINE RELEASE; RECEPTOR KNOCKOUT MICE; IN-VIVO MICRODIALYSIS; HUMAN CEREBRAL-CORTEX; ALZHEIMERS-DISEASE; NUCLEUS-ACCUMBENS; FOS EXPRESSION; BEHAVIORAL SYMPTOMS; M2-MUSCARINIC DRUGS;
Keywords:
xanomeline; muscarinic agonist; schizophrenia; antipsychotic; neurotransmitter release; gene expression; Fos;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Bymaster, FP Eli Lilly & Co, Lilly Corp Ctr, Lilly Res Labs, Neurosci Res Div, Indianapolis, IN 46285 USA Eli Lilly & Co Indianapolis IN USA 46285 polis, IN 46285 USA
Citazione:
K.W. Perry et al., "The muscarinic agonist xanomeline increases monoamine release and immediate early gene expression in the rat prefrontal cortex", BIOL PSYCHI, 49(8), 2001, pp. 716-725

Abstract

Background: The muscarinic agonist xanomeline has been shown to reduce antipsychotic-like behaviors in patients with Alzheimer's disease. Because atypical antipsychotic agents increase dopamine release in prefrontal cortex and induce immediate early gene expression in prefrontal cortex and nucleus accumbens. the effect of xanomeline was determined on these indices. Methods: The effect of xanomeline on extracellular levels of monoamines inbrain regions was determined using a microdialysis technique, and changes in expression of the immediate early genes c-fos and zif/268 in brain regions were evaluated using in situ hybridization histochemistry. Results: Xanomeline increased extracellular levels of dopamine in prefrontal cortex and nucleus accumbens but not in striatum. Xanomeline increased expression of c-fos and zif/268 in prefrontal cortex and nucleus accumbens. There was no change in immediate early gene expression in striatum. Conclusions: Xanomeline increased extracellular levels of dopamine, which is similar to the effects of the atypical antipsychotics clozapine and olanzapine. The regional pattern of immediate early gene expression induced by xanomeline resembled that of atypical antipsychotic agents. Based on the antipsychotic-like activity of xanomeline in Alzheimer's patients and the similarity to atypical antipsychotic agents, we suggest that xanomeline may bea novel antipsychotic agent. (C) 2001 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 15:02:02