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Titolo:
Are auditory hallucinations the consequence of abnormal cerebral lateralization? A morphometric MRI study of the sylvian fissure and planum temporale
Autore:
Shapleske, J; Rossell, SL; Simmons, A; Davis, AS; Woodruff, PWR;
Indirizzi:
Inst Psychiat, Sect Cognit Neuropsychiat, London SE5 8AF, England Inst Psychiat London England SE5 8AF ropsychiat, London SE5 8AF, England Inst Psychiat, Neuroimaging Unit, London SE5 8AF, England Inst Psychiat London England SE5 8AF aging Unit, London SE5 8AF, England GKT Sch Med, London, England GKT Sch Med London EnglandGKT Sch Med, London, England No Gen Hosp, Longley Ctr, Dept Psychiat, Sheffield S5 7AU, S Yorkshire, England No Gen Hosp Sheffield S Yorkshire England S5 7AU AU, S Yorkshire, England
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 8, volume: 49, anno: 2001,
pagine: 685 - 693
SICI:
0006-3223(20010415)49:8<685:AAHTCO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
THOUGHT-DISORDER; HEMISPHERIC ASYMMETRIES; TOMOGRAPHIC SCANS; VOLUME REDUCTION; CORPUS-CALLOSUM; LEFT-HANDERS; SCHIZOPHRENIA; GYRUS; MORPHOLOGY; SPEECH;
Keywords:
auditory hallucinations; planum temporale; sylvian fissure; magnetic resonance imaging; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Davis, AS Inst Psychiat, Sect Cognit Neuropsychiat, London SE5 8AF, England Inst Psychiat London England SE5 8AF , London SE5 8AF, England
Citazione:
J. Shapleske et al., "Are auditory hallucinations the consequence of abnormal cerebral lateralization? A morphometric MRI study of the sylvian fissure and planum temporale", BIOL PSYCHI, 49(8), 2001, pp. 685-693

Abstract

Background: Auditory verbal hallucinations (AVHs) are a characteristic feature of schizophrenia. Patients with schizophrenia have been found to have reduced volumes of a variety of brain structures as well as a reduction in right-left asymmetries, using postmortem and magnetic resonance imaging (MRI) measures. There is also evidence that patients with AVHs differ in thesestructural asymmetries, relative to those patients who do nor hallucinate. The aim of this study was to examine whether patients with and without a prominent history of AVHs differ both from each other and in comparison withnormal subjects, in the asymmetry of the sylvian fissure (SF) and planum temporale (PT),Methods: We recruited 74 DSM-IV male patients with schizophrenia (on the basis of their AVH history) and 32 marched normal control subjects. Thirty patients had no history of AVHs and 44 had a strong definitive history of AVHs. The SF length and PT area and volume were measured on a three-dimensional MRI spoiled GRASS volume sequence. Absolute measures and laterality coefficients were calculated. Results: All groups had the normal leftward asymmetry in both the SF and PT. Planum temporale volume and surface area and SF length were all larger in the left hemisphere. There were no significant differences in any measures between the two patient groups or between schizophrenic patients and control subjects. Greater leftward asymmetry of the SF correlated with hallucinations and thought disorder within the prominent hallucinator group. An association was found between handedness and brain size, bur this did not interact with diagnosis. Conclusions: The results of this study do nor confirm reports, based on smaller samples, of reduced structural asymmetries of either the SF or PT in schizophrenia, nor do they indicate a specific relationship to a propensityto experience AVHs. A modest correlation between leftward asymmetry of theSF and some positive symptomatology was found (C) 2001 Society of Biological Psychiatry.

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Documento generato il 22/01/20 alle ore 09:43:12