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Titolo:
Regional cortical white matter reductions in velocardiofacial syndrome: A volumetric MRI analysis
Autore:
Kates, WR; Burnette, CP; Jabs, EW; Rutberg, J; Murphy, AM; Grados, M; Geraghty, M; Kaufmann, WE; Pearlson, GD;
Indirizzi:
Johns Hopkins Univ, Sch Med, Div Psychiat Neuroimaging, Baltimore, MD 21287 USA Johns Hopkins Univ Baltimore MD USA 21287 maging, Baltimore, MD 21287 USA Johns Hopkins Univ, Sch Med, Kennedy Krieger Inst, Baltimore, MD 21287 USAJohns Hopkins Univ Baltimore MD USA 21287 r Inst, Baltimore, MD 21287 USA Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21287 USA Johns Hopkins Univ Baltimore MD USA 21287 av Sci, Baltimore, MD 21287 USA Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21287 USA Johns Hopkins Univ Baltimore MD USA 21287 Pediat, Baltimore, MD 21287 USA Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21287 USA Johns Hopkins Univ Baltimore MD USA 21287 pt Med, Baltimore, MD 21287 USA Johns Hopkins Univ, Sch Med, Dept Plast Surg, Baltimore, MD 21287 USA Johns Hopkins Univ Baltimore MD USA 21287 t Surg, Baltimore, MD 21287 USA Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21287 USA Johns Hopkins Univ Baltimore MD USA 21287 Pathol, Baltimore, MD 21287 USA Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21287 USA Johns Hopkins Univ Baltimore MD USA 21287 Neurol, Baltimore, MD 21287 USA Johns Hopkins Univ, Sch Publ Hlth, Dept Mental Hyg, Baltimore, MD 21287 USA Johns Hopkins Univ Baltimore MD USA 21287 al Hyg, Baltimore, MD 21287 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 8, volume: 49, anno: 2001,
pagine: 677 - 684
SICI:
0006-3223(20010415)49:8<677:RCWMRI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIO-FACIAL SYNDROME; HUMAN BRAIN; CHROMOSOME 22Q11; SCHIZOPHRENIA; DISORDERS; CHILDREN; ANOMALIES; DELETION; INTELLIGENCE; PARCELLATION;
Keywords:
velocardiofacial syndrome; volumetric MRI; chromosome 22q11; cerebral lobes; white matter;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Kates, WR Johns Hopkins Univ, Sch Med, Div Psychiat Neuroimaging, 600 N Wolfe St,Meyer 3-166, Baltimore, MD 21287 USA Johns Hopkins Univ 600 N Wolfe St,Meyer 3-166 Baltimore MD USA 21287
Citazione:
W.R. Kates et al., "Regional cortical white matter reductions in velocardiofacial syndrome: A volumetric MRI analysis", BIOL PSYCHI, 49(8), 2001, pp. 677-684

Abstract

Background: Velocardiofacial syndrome, caused by a microdeletion on chromosome 22q.11, is associated with craniofacial anomalies, cardiac defects, learning disabilities, and psychiatric disorders. To understand how the 22q.11 deletion affects brain development, this study examined gray and white matter volumes in major lobar brain regions of children with velocardiofacialsyndrome relative to control subjects. Methods: Subjects were ten children with velocardiofacial syndrome and tenage- and gender-matched unaffected children. Coronal images were acquired with a 3-D spoiled gradient echo series and partitioned into 124. 1.5-mm contiguous slices. A stereotaxic grid was used to subdivide brain tissue intocerebral lobes, which were segmented into gray, white, and CSF compartments using an algorithm based on intensity values and tissue boundaries. Nonparametric statistics were used to compare lobar volumes of gray and white matter. Results: Analyses indicated that children with velocardiofacial syndrome had significantly smaller volumes in nonfrontal, but not frontal, lobar brain regions. Volume reductions affected nonfrontal white matter to a greater extent than nonfrontal gray matter. Conclusions: The presence of white matter reductions may be related to disturbances in myelination or axonal integrity in velocardiofacial syndrome. Further work is required to delineate the nature and extent of white matteranomalies. and to link them to variation in the neurocognitive and neuropsychiatric phenotype of velocardiofacial syndrome. (C) 2001 Society Of Biological Psychiatry.

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Documento generato il 04/04/20 alle ore 15:13:28