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Titolo:
Dissociation between the effects of pre-weaning and/or post-weaning socialisolation on prepulse inhibition and latent inhibition in adult Sprague-Dawley rats
Autore:
Weiss, IC; Domeney, AM; Moreau, JL; Russig, H; Feldon, J;
Indirizzi:
ETH, Behav Neurobiol Lab, Zurich, Switzerland ETH Zurich SwitzerlandETH, Behav Neurobiol Lab, Zurich, Switzerland F Hoffmann La Roche & Co Ltd, CH-4002 Basel, Switzerland F Hoffmann La Roche & Co Ltd Basel Switzerland CH-4002 asel, Switzerland
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1-2, volume: 121, anno: 2001,
pagine: 207 - 218
SICI:
0166-4328(200106)121:1-2<207:DBTEOP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC STARTLE RESPONSE; STRESSFUL LIFE EVENT; MATERNAL SEPARATION; SEX-DIFFERENCES; GLUCOCORTICOID RECEPTORS; SCHIZOPHRENIC-PATIENTS; STRAIN DIFFERENCES; NUCLEUS-ACCUMBENS; ANIMAL-MODEL; WISTAR RATS;
Keywords:
animal model; gender; latent inhibition; maternal separation; prepulse inhibition; schizophrenia; social isolation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Feldon, J ETH, Behav Neurobiol Lab, Zurich, Switzerland ETH Zurich Switzerland hav Neurobiol Lab, Zurich, Switzerland
Citazione:
I.C. Weiss et al., "Dissociation between the effects of pre-weaning and/or post-weaning socialisolation on prepulse inhibition and latent inhibition in adult Sprague-Dawley rats", BEH BRA RES, 121(1-2), 2001, pp. 207-218

Abstract

Human attentional impairments can be modelled in the rat using the prepulse inhibition (PPT) or the latent inhibition (LI) paradigm. The present study investigated the consequences of a combination of pre-weaning maternal separation (MS) and post-weaning social isolation (ST) on both PPI and LI in male and female Sprague-Dawley rats tested as adults. We report here a double dissociation between the effects of MS (repeated 4 h daily separations) and SI on PPI and LI: MS did not modify PPI, but enhanced LI. In contrast, SI disrupted PPI, the deficits being restricted to male rats, but left LI intact. There were no additive effects of MS and SI on PPI or LI. While MS improved avoidance learning, SI impaired it. Although both PPI and LI assessprocesses of selective attention, our results support the contention, already stated in the literature, that they involve differing neuro-psychological mechanisms. Furthermore, the fact that only males exhibited PPI deficitsfollowing SI has implications for the well-known differential vulnerability of human males to certain psychiatric disorders (e.g, schizophrenia). Finally, the combination of MS and SI could represent a relevant animal model for some aspects of schizophrenia, since both PPI and LI were altered. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 20/11/19 alle ore 03:35:21