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Titolo:
Dose- and time-dependent scopolamine-induced recovery of an inhibitory avoidance response after its extinction in rats
Autore:
Roldan, G; Cobos-Zapiain, G; Quirarte, GL; Prado-Alcala, RA;
Indirizzi:
Univ Nacl Autonoma Mexico, Fac Med, Dept Fisiol, Mexico City 04510, DF, Mexico Univ Nacl Autonoma Mexico Mexico City DF Mexico 04510 y 04510, DF, Mexico Univ Nacl Autonoma Mexico, ENEP Iztacala, Mexico City 04510, DF, Mexico Univ Nacl Autonoma Mexico Mexico City DF Mexico 04510 y 04510, DF, Mexico Univ Nacl Autonoma Mexico, Ctr Neurobiol, Queretaro, Mexico Univ Nacl Autonoma Mexico Queretaro Mexico Neurobiol, Queretaro, Mexico
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1-2, volume: 121, anno: 2001,
pagine: 173 - 179
SICI:
0166-4328(200106)121:1-2<173:DATSRO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLINERGIC DRUG-COMBINATIONS; ANTAGONIST MK-801 BLOCKS; ACTH-INDUCED RECOVERY; PASSIVE-AVOIDANCE; ACTIVE-AVOIDANCE; NMDA ANTAGONIST; CAUDATE-NUCLEUS; MEMORY; ACQUISITION; MICE;
Keywords:
learning; memory; extinction; acetylcholine; scopolamine; behavioural recovery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Roldan, G Univ Nacl Autonoma Mexico, Fac Med, Dept Fisiol, POB 70-250, Mexico City 04510, DF, Mexico Univ Nacl Autonoma Mexico POB 70-250 Mexico CityDF Mexico 04510
Citazione:
G. Roldan et al., "Dose- and time-dependent scopolamine-induced recovery of an inhibitory avoidance response after its extinction in rats", BEH BRA RES, 121(1-2), 2001, pp. 173-179

Abstract

The present investigation was aimed at elucidating the dose and time dependency of scopolamine-induced recovery of inhibitory avoidance after its extinction. Two experiments were conducted: in the first, we analyzed the effects of four doses (1, 2, 4, and 8 mg/kg) of the musacrinic receptor antagonist scopolamine, on the expression of this conditioned response once it hadbeen extinguished. Independent groups of rats were trained in a one-trial,step-through inhibitory avoidance task and submitted to daily retention (extinction) tests. After extinction had occurred, animals were injected intraperitoneally 10 min before retention testing, either with saline or scopolamine. Results show that scopolamine produced a dose-dependent recovery of the avoidance response. The second experiment was carried out in the same animals. which were now tested for retention of inhibitory avoidance at 1, 2, 3, 6, and 9 months after completion of the first experiment. All rats received counterbalanced injections of saline or scopolamine 10 min before testing at each time interval. Reliable recovery of the avoidance response wasobserved at the 1-month interval with a clear dose dependency while, afterthe second month, only the groups treated with the two higher doses continued responding. The results indicate that recovery of the extinguished response produced by muscarinic blockade follows dose- and time-dependent curves. and can be achieved long after a single training session. These data suggest that the inhibitory avoidance memory trace is retained in the brain after behavioural extinction of this response, thus supporting the view of extinction as new learning that affects the retrieval of the original memory,but does not modify its storage. (C) 2001 Elsevier Science B.V. All rightsreserved.

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Documento generato il 19/01/20 alle ore 09:14:25