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Titolo:
Mechanisms of acute coronary syndromes and the potential role of statins
Autore:
Dupuis, J;
Indirizzi:
Inst Cardiol Montreal, Ctr Rech, Montreal, PQ H1T 1C8, Canada Inst CardiolMontreal Montreal PQ Canada H1T 1C8 real, PQ H1T 1C8, Canada
Titolo Testata:
ATHEROSCLEROSIS SUPPLEMENTS
fascicolo: 1, volume: 2, anno: 2001,
pagine: 9 - 14
SICI:
1567-5688(200102)2:1<9:MOACSA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-REACTIVE PROTEIN; ACUTE MYOCARDIAL-INFARCTION; COA REDUCTASE INHIBITORS; NITRIC-OXIDE SYNTHASE; SMOOTH-MUSCLE CELLS; CHOLESTEROL REDUCTION; LOVASTATIN THERAPY; PLAQUE DISRUPTION; CLINICAL EVENTS; PRAVASTATIN;
Keywords:
coronary; statins; lesions;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Dupuis, J Inst Cardiol Montreal, Ctr Rech, 5000 Est Rue Belanger, Montreal, PQ H1T 1C8, Canada Inst Cardiol Montreal 5000 Est Rue Belanger Montreal PQ Canada H1T 1C8
Citazione:
J. Dupuis, "Mechanisms of acute coronary syndromes and the potential role of statins", ATHEROSCL S, 2(1), 2001, pp. 9-14

Abstract

The conventional concepts of the pathogenesis of acute coronary syndromes are changing. High-risk lesions are not necessarily the angiographicaly 'tight' stenoses. Rather, vulnerable lesions are those that are unstable, witha large lipid core and a thin fibrous cap. Plaque instability is closely related to the development of inflammation within the intima and acute coronary syndromes result from rupture of a vulnerable atherosclerotic plaque. Stabilization of lesions by modification of structure and content, rather than simple improvement in the luminal diameter, provides a new therapeutic target. Stabilization may be accomplished through lifestyle changes and appropriate pharmacologic therapy. In the past few years, it has become evidentthat a major beneficial effect of statins is to induce plaque stability and regression. In fact, statins, in addition to lowering low-density lipoprotein cholesterol, have a variety of pleiotropic, or cholesterol-independent, effects that make them a particularly suitable choice in patients with acute coronary syndromes. Among these are improvements in endothelial function, smooth muscle cells, thrombus formation/platelet function, and inflammation. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:43:58