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Titolo:
Dynamics of (Cd,Zn)-metallothioneins in gills, liver and kidney of common carp Cyprinus carpio during cadmium exposure
Autore:
De Smet, H; De Wachter, B; Lobinski, R; Blust, R;
Indirizzi:
Univ Antwerp, RUCA, Dept Biol, B-2020 Antwerp, Belgium Univ Antwerp Antwerp Belgium B-2020 , Dept Biol, B-2020 Antwerp, Belgium Univ Pau & Pays Adour, Lab Chim Bioinorgan & Environm, F-64000 Pau, FranceUniv Pau & Pays Adour Pau France F-64000 & Environm, F-64000 Pau, France
Titolo Testata:
AQUATIC TOXICOLOGY
fascicolo: 3-4, volume: 52, anno: 2001,
pagine: 269 - 281
SICI:
0166-445X(200105)52:3-4<269:DO(IGL>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
METAL INTRACELLULAR BALANCE; RAINBOW-TROUT; METALLOTHIONEIN INDUCTION; SALMO-GAIRDNERI; TISSUES; SPECTROMETRY; ACCUMULATION; SILVER; FISH; QUANTIFICATION;
Keywords:
metallothionein synthesis; (Cd,Zn)-metallothionein concentration; (Cd,Zn)-metallothionein saturation; Cyprinus carpio; cadmium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Blust, R Univ Antwerp, RUCA, Dept Biol, Groenenborgerlaan 171, B-2020 Antwerp, Belgium Univ Antwerp Groenenborgerlaan 171 Antwerp Belgium B-2020 elgium
Citazione:
H. De Smet et al., "Dynamics of (Cd,Zn)-metallothioneins in gills, liver and kidney of common carp Cyprinus carpio during cadmium exposure", AQUAT TOX, 52(3-4), 2001, pp. 269-281

Abstract

Cadmium concentrations, (Cd,Zn)-metallothionein (MT) concentrations, MT synthesis and the relative amounts of cadmium bound to (Cd,Zn)-MTs were determined in gills, liver and kidney of common carp Cyprinus carpio exposed to 0, 0.5 muM (0.06 mg.l(-1)), 2.5 muM (0.25 mg.l(-1)) and 7 muM (0.79 mg.l(-1)) Cd for up to 29 days. Cadmium accumulation was in the order kidney > liver > gills. Control levels of hepatic (Cd,Zn)-MT were four times higher compared to these of gills and kidney. No increases in (Cd,Zn)-MT concentrations were observed in liver during the exposure period. In comparison with control carp, (Cd,Zn)-MT concentrations increased up to 4.5 times in kidney and two times in gills. In both these organs, (Cd,Zn)-MT concentrations werelinearly related with cadmium tissue levels and with the de novo synthesisof MTs. Hepatic cadmium was almost completely bound to (Cd,Zn)-MT, while percentages of non-MT-bound cadmium were at least 40% in gills and 25% in kidney. This corresponded with a total saturation of (Cd,Zn)-MT by cadmium inkidney and a saturation of approximately 50 and 60% in gills and liver, respectively. The final order of non-MT-bound cadmium was kidney > gills > liver. Our results indicate that cadmium exposure causes toxic effects, whichcannot be correlated with the accumulated levels of the metal in tissues. Although cadmium clearly leads to the de novo synthesis of MT and higher (Cd,Zn)-MT concentrations, the role of this protein in the detoxification process is clearly organ-specific and its synthesis does not keep track with cadmium accumulation. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 12:39:33