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Titolo:
Serum levels of angiogenin (ANG) in invasive cervical cancer and in cervical intraepithelial neoplasia (CIN)
Autore:
Bodner-Adler, B; Hefler, L; Bodner, K; Leodolter, S; Frischmuth, K; Kainz, C; Mayerhofer, K;
Indirizzi:
Univ Vienna, Sch Med, Dept Obstet & Gynecol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 stet & Gynecol, A-1090 Vienna, Austria
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 1B, volume: 21, anno: 2001,
pagine: 809 - 812
SICI:
0250-7005(200101/02)21:1B<809:SLOA(I>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPRESSION;
Keywords:
cervical cancer; cervical intraepithelial neoplasia; serum angiogenin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Mayerhofer, K Univ Vienna, Sch Med, Dept Obstet & Gynecol, Wahringer Gurtel 18-20, A-1090 Vienna, Austria Univ Vienna Wahringer Gurtel 18-20 Vienna Austria A-1090 ia
Citazione:
B. Bodner-Adler et al., "Serum levels of angiogenin (ANG) in invasive cervical cancer and in cervical intraepithelial neoplasia (CIN)", ANTICANC R, 21(1B), 2001, pp. 809-812

Abstract

Background: The propensity of malignant tumors to increase in size to invade locally and to metastasize is dependent on angiogenesis, which is induced by a variety of proteins including the family of fibroblast growth factors, vascular endothelial growth factor and angiogenin (ANG). The aim of the present study was to measure the serum levels of ANG in patients with CIN and invasive cervical cancer and to evaluate a possible correlation between ANG and various clinicopathologic parameters. Materials and Methods: Blood was collected from 62 patients with invasive cervical cancer and 47 patients with GIN. Serum samples of 30 age-matched healthy women acting as a control group were obtained. Determination of serum levels of ANG was performed using a quantitative human ANG immunoassay. Results: The overall median ANGserum level was 272.0 pg/ml (range 101.6-869.2). The median serum levels of ANG were 248.9 (range 101.6-307.2) for healthy female cona ols, 246.5 (range 169.7-468.1) for patients with CIN and 308.1 pg/ml (range 180.1-869.2) for patients with invasive cervical cancer: Serum levels of ANG were significantly elevated in patients with invasive cervical cancer compared with patients with CIN (p <0.05) as well as healthy female controls (p <0.05). No difference was found between ANG serum levels in women with GIN, and healthy controls (p<0.05). No correlations were found between serum levels of ANGand clinico-pathologic parameters (p>0.05). Conclusions: Our data indicatethe important role of ANG in tumor angiogenesis in invasive cervical cancer as ANG serum levels were significantly elevated in these patients. However; elevated ANG serum levels seem to occur. only after the transformation from pre-invasive to invasive lesions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 10:28:11