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Titolo:
Immunohistochemical detection of p53 protein expression in breast cancer in young Kuwaiti women
Autore:
Temmim, L; Baker, H; Sinowatz, F;
Indirizzi:
Univ Munich, Fac Vet, Inst Histol & Embryol, D-80539 Munich, Germany Univ Munich Munich Germany D-80539 ol & Embryol, D-80539 Munich, Germany Kuwait Canc Control Ctr, Kuwait, Kuwait Kuwait Canc Control Ctr Kuwait Kuwait Canc Control Ctr, Kuwait, Kuwait
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 1B, volume: 21, anno: 2001,
pagine: 743 - 748
SICI:
0250-7005(200101/02)21:1B<743:IDOPPE>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-SUPPRESSOR GENE; PROGNOSIS; CELLS; ASSOCIATION; ANTIBODIES; CARCINOMAS; INDICATOR; MUTATIONS; MARKERS; LUNG;
Keywords:
p53; breast cancer; young patients; Kuwait;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Sinowatz, F Univ Munich, Fac Vet, Inst Histol & Embryol, Vet Str 13, D-80539 Munich, Germany Univ Munich Vet Str 13 Munich Germany D-80539 Munich, Germany
Citazione:
L. Temmim et al., "Immunohistochemical detection of p53 protein expression in breast cancer in young Kuwaiti women", ANTICANC R, 21(1B), 2001, pp. 743-748

Abstract

The mutation of the p53 gene is a common phenomenon in numerous human tumors including breast cancer: It leads to an accumulation of nonfunctioning p53 protein in the cell nuclei, which can be detected by immunohistochemicaltechniques. lit breast cancer overexpression of mutated p53 protein has been correlated to a poor prognosis. Our study is an immunohistochemical analysis of p53 in 82 cases of breast cancel in young (less than or equal to 30yeats old) Kuwaiti women, correlating it with histopathological grade, lymph node status estrogen (ER) and progesterone receptor (PgR) content, tumorcell proliferation (immunostaining for Ki-67) and expression of c-erbB-2 oncoprotein. p53 immunostaining was found in 47 (57.32%) of the carcinomas. 65% of them displayed positive immunostaining for c-erbB-2. 63.7% of tumorswith p53 overexpression were aneuploid 64.8% of the p53 positive tumors were node positive. 93.5% of the p53 immunopositive carcinomas were ER-negative, and in 95,7% of this subclass of patients no PgR could be detected. Thevast majority of p53 positive carcinomas were grade III (76.6%), 21.3% were grade II and 2,1% grade I, but neither tumor grade or tumor size showed acon elation with p53 expression. A significant negative correlation between ER- and PgR-content (p = 0,006) and immunostaining for p53 was observed. Our study provided evidence that the association of negative hormone receptor status and positivity for p53 immunostaining points to a greater tumor aggressiveness.

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Documento generato il 04/12/20 alle ore 20:59:03