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Titolo:
Maternal glucocorticoid treatment programs HPA regulation in adult offspring: sex-specific effects
Autore:
Liu, L; Li, AT; Matthews, SG;
Indirizzi:
Univ Toronto, Fac Med, Dept Physiol, Toronto, ON M5S 1A8, Canada Univ Toronto Toronto ON Canada M5S 1A8 ysiol, Toronto, ON M5S 1A8, Canada Univ Toronto, Fac Med, Dept Obstet & Gynecol, Toronto, ON M5S 1A8, Canada Univ Toronto Toronto ON Canada M5S 1A8 necol, Toronto, ON M5S 1A8, Canada
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
fascicolo: 5, volume: 280, anno: 2001,
pagine: E729 - E739
SICI:
0193-1849(200105)280:5<E729:MGTPHR>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING HORMONE; PITUITARY-ADRENAL RESPONSES; RECEPTOR MESSENGER-RNA; GUINEA-PIG BRAIN; LATE-GESTATION; STRESS; DEXAMETHASONE; GROWTH; CORTICOSTEROIDS; EXPRESSION;
Keywords:
dexamethasone; glucocorticoid receptor; mineralocorticoid receptor; limbic system; hypothalamo-pituitary-adrenal axis; programming;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Matthews, SG Univ Toronto, Fac Med, Dept Physiol, Med Sci Bldg,1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada Univ Toronto Med Sci Bldg,1 Kings Coll Circle Toronto ON Canada M5S 1A8
Citazione:
L. Liu et al., "Maternal glucocorticoid treatment programs HPA regulation in adult offspring: sex-specific effects", AM J P-ENDO, 280(5), 2001, pp. E729-E739

Abstract

Pregnant guinea pigs were treated with dexamethasone (1 mg/kg) or vehicle on days 40-41, days 50-51, and days 60-61 of gestation. Adult offspring were split into two groups. Group 1 guinea pigs were catheterized, and the hypothalamo-pituitary-adrenal (HPA) axis was tested in basal and activated states. Group 2 guinea pigs were euthanized with no further manipulation. In male offspring, prenatal dexamethasone exposure resulted in a significant reduction in brain-to-body weight ratio. Dexamethasone-exposed male offspringexhibited reduced basal and activated plasma cortisol levels, which was associated with elevated hippocampal mineralocorticoid receptor (MR) mRNA andincreased plasma testosterone. In females exposed to glucocorticoids in utero, basal and stimulated plasma cortisol levels were higher in the follicular and early luteal phases of the cycle, but this effect was reversed in the late luteal phase, indicating a significant interaction of sex steroids. In female offspring (at estrus), glucocorticoid receptor mRNA levels were lower in the paraventricular nucleus and pars distalis but higher in the hippocampus in animals exposed to dexamethasone in utero. Hippocampal MR mRNAlevels were significantly lower (similar to 50%) than in controls. In conclusion, repeated antenatal glucocorticoid treatment programs HPA function in a sex-specific manner, and these changes are associated with modificationof corticosteroid receptor expression in the adult brain and pituitary.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:07:53