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Titolo:
c-Myb and Bcl-x overexpression predicts poor prognosis in colorectal cancer - Clinical and experimental findings
Autore:
Biroccio, A; Benassi, B; DAgnano, I; DAngelo, C; Buglioni, S; Mottolese, M; Ricciotti, A; Citro, G; Cosimelli, M; Ramsay, RG; Calabretta, B; Zupi, G;
Indirizzi:
Regina Elena Canc Inst, Expt Res Ctr, Lab Expt Chemotheraphy, I-00158 Rome, Italy Regina Elena Canc Inst Rome Italy I-00158 otheraphy, I-00158 Rome, Italy Regina Elena Canc Inst, Dept Pathol, I-00158 Rome, Italy Regina Elena CancInst Rome Italy I-00158 pt Pathol, I-00158 Rome, Italy Regina Elena Canc Inst, Dept Surg, I-00158 Rome, Italy Regina Elena Canc Inst Rome Italy I-00158 Dept Surg, I-00158 Rome, Italy Peter MacCallum Canc Inst, Melbourne, Vic 3000, Australia Peter MacCallum Canc Inst Melbourne Vic Australia 3000 ic 3000, Australia Thomas Jefferson Univ, Kimmel Canc Inst, Dept Microbiol & Immunol, Philadelphia, PA USA Thomas Jefferson Univ Philadelphia PA USA Immunol, Philadelphia, PA USA Univ Modena, Dept Biomed Sci, Modena, Italy Univ Modena Modena ItalyUniv Modena, Dept Biomed Sci, Modena, Italy
Titolo Testata:
AMERICAN JOURNAL OF PATHOLOGY
fascicolo: 4, volume: 158, anno: 2001,
pagine: 1289 - 1299
SICI:
0002-9440(200104)158:4<1289:CABOPP>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTISENSE OLIGODEOXYNUCLEOTIDES; ONCOPROTEIN EXPRESSION; P53 MUTATIONS; DNA-PLOIDY; APOPTOSIS; CELLS; GENE; ADENOCARCINOMAS; TUMORIGENESIS; CARCINOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Zupi, G Regina Elena Canc Inst, Expt Res Ctr, Lab Expt Chemotheraphy, Via Messi Doro 156, I-00158 Rome, Italy Regina Elena Canc Inst Via Messi Doro 156 Rome Italy I-00158 taly
Citazione:
A. Biroccio et al., "c-Myb and Bcl-x overexpression predicts poor prognosis in colorectal cancer - Clinical and experimental findings", AM J PATH, 158(4), 2001, pp. 1289-1299

Abstract

The aim of this study was twofold: to assess the relationship between c-Myb, and Bcl-x expression and to evaluate the prognostic significance of their expression in colorectal carcinoma (CRC) patients. Analysis of tumors from 91 CRC patients for expression of c-Myb and Bcl-x revealed a significant relationship between these two proteins. Kaplan-Meier's analysis showed an increased risk of relapse and death in patients whose tumor specimens displayed high c-Myb levels and Bcl-x positivity. Similar results were also observed excluding Dukes' D patients. Molecular analysis using three c-Myb-overexpressing LoVo clones indicated that c-Myb overexpression was accompanied by up-regulation of Bcl-x, protein and rnRNA. Tumors originating from theseclones Injected in nude mice were significantly larger than those formed in mice injected with parental or vector-transfected LoVo cells. Moreover, tumors derived from parental and control vector-transfected but not from c-Myb-overexpressing LoVo cells showed high frequency of apoptotic cells. These results provide direct evidence of an association between c-Myb, and Bcl-x expression and suggest that expression of both molecules might be a useful prognostic marker in CRC.

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Documento generato il 21/09/20 alle ore 19:05:54