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Titolo:
Human twinning is not linked to the region of chromosome 4 syntenic with the sheep twinning gene FecB
Autore:
Duffy, DL; Montgomery, GW; Hall, J; Mayne, C; Healey, SC; Brown, J; Boomsma, DI; Martin, NG;
Indirizzi:
Univ Queensland, Queensland Inst Med Res, Genet Epidemiol Unit, Brisbane, Qld, Australia Univ Queensland Brisbane Qld Australia ol Unit, Brisbane, Qld, Australia Univ Queensland, Joint Genet Program, Brisbane, Qld, Australia Univ Queensland Brisbane Qld Australia Program, Brisbane, Qld, Australia AxyS Pharmaceut Inc, La Jolla, CA USA AxyS Pharmaceut Inc La Jolla CA USA xyS Pharmaceut Inc, La Jolla, CA USA Univ Otago, Dept Biochem, AgRes Mol Biol Unit, Dunedin, New Zealand Univ Otago Dunedin New Zealand gRes Mol Biol Unit, Dunedin, New Zealand Free Univ Amsterdam, Dept Psychol, Amsterdam, Netherlands Free Univ Amsterdam Amsterdam Netherlands ychol, Amsterdam, Netherlands
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 3, volume: 100, anno: 2001,
pagine: 182 - 186
SICI:
0148-7299(20010501)100:3<182:HTINLT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUS DIZYGOTIC TWINS; OVULATION RATE; ACIDIC PHOSPHOPROTEIN; LINKAGE ANALYSIS; X-CHROMOSOME; HORMONE; MOTHERS; FOLLICLE; MARKERS; INHIBIN;
Keywords:
dizygotic twinning; genetic linkage; Booroola sheep;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Duffy, DL PO Royal Brisbane Hosp, Queensland Inst Med Res, Brisbane, Qld 4029, Australia PO Royal Brisbane Hosp Brisbane Qld Australia 4029 9, Australia
Citazione:
D.L. Duffy et al., "Human twinning is not linked to the region of chromosome 4 syntenic with the sheep twinning gene FecB", AM J MED G, 100(3), 2001, pp. 182-186

Abstract

The tendency to dizygotic (DZ) twinning is inherited in both humans and sheep, and a fecundity gene in sheep (FecB) maps to sheep chromosome 6, syntenic with human 4q21-25. Our aim was to see whether a gene predisposing to human DZ twinning mapped to this region. DNA was collected from 169 pairs and 17 sets of 3 sisters (trios) from Australia and New Zealand who had each had spontaneous DZ twins, mostly before the age of 35, and from a replication sample of 111 families (92 affected sister pairs) from The Netherlands. Exclusion mapping was carried out after typing 26 markers on chromosome 4, of which 8 spanned the region Likely to contain the human homologue of the sheep FecB gene. We used nonparametric affected sib pair methods for linkage analysis [ASPEX 2.2, Hinds and Risch, 1999]. Complete exclusion of linkage (lod < -2) of a gene conferring a relative risk for sibs as low as 1.5 (<lambda>(s) > 1.5) was obtained for all but the p terminus region on chromosome 4. Exclusion in the syntenic region was stronger, down to lambda (s) = 1.3. We concluded that if there is a gene influencing DZ twinning on chromosome 4, its effect must be minor. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:55:19