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Titolo:
Association between Albumin : Creatinine ratio and 24-hour ambulatory blood pressure in essential hypertension
Autore:
Boulatov, VA; Stenehjem, A; Os, I;
Indirizzi:
Univ Oslo, Ullevaal Hosp, Dept Nephrol, N-0407 Oslo, Norway Univ Oslo Oslo Norway N-0407 aal Hosp, Dept Nephrol, N-0407 Oslo, Norway
Titolo Testata:
AMERICAN JOURNAL OF HYPERTENSION
fascicolo: 4, volume: 14, anno: 2001,
parte:, 1
pagine: 338 - 344
SICI:
0895-7061(200104)14:4<338:ABA:CR>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICULAR HYPERTROPHY; CARDIOVASCULAR RISK-FACTORS; EXCRETION RATE; HEALTHY-SUBJECTS; MICROALBUMINURIA; PREVALENCE; POPULATION; INDIVIDUALS; MARKER; MILD;
Keywords:
microalbuminuria; essential hypertension; ambulatory blood pressure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Os, I Univ Oslo, Ullevaal Hosp, Dept Nephrol, N-0407 Oslo, Norway Univ Oslo Oslo Norway N-0407 sp, Dept Nephrol, N-0407 Oslo, Norway
Citazione:
V.A. Boulatov et al., "Association between Albumin : Creatinine ratio and 24-hour ambulatory blood pressure in essential hypertension", AM J HYPERT, 14(4), 2001, pp. 338-344

Abstract

Microalbuminuria (MAU) is often found in essential hypertension (EH) and represents a sign of renal and cardio-vascular damage. In the present study,we aimed to look at the association between ambulatory blood pressure (BP)and urinary albumin excretion (UAE), We studied 140 patients aged 50.1 +/-11.6 years referred for 24-h ambulatory blood pressure monitoring (ABPM) and, separately 46 untreated subjects with newly diagnosed EH. Urinary albumin excretion was evaluated by determination of the albumin-to-creatinine ratio (ACR) in the first voided morning urine sample taken the same day as the ABPM was started. According to the ACR, patients were categorized as having nornoalbuminuria (ACR <1.5 mg/mmol), borderline MAU (1.5 <less than or equal to> ACR <3.0 mg/mmol), and overt MAU (ACR <greater than or equal to>3.0 mg/mmol). Mean ACR was significantly higher in hypertensive than normotensive individuals (2.17 +/- 2.67 mg/mmol and 1.72 +/- 2.97 mg/mmol, respectively, P = .012), Average 24-h, daytime and nighttime systolic BP and diastolic BP werelower in patients with normoalbuminuria than in the other two groups and did not differ among the two microalbuminuric groups. Univariate regression analysis showed a close relationship between ACR and ambulatory BP, Strong correlation between BP and ACR in the normoalbuminuric and borderline microalbuminuric range was also obtained in the group of 46 newly diagnosed hypertensive patients. In conclusion, the threshold level of ACR greater than or equal to3.0 mg/mmol currently used to define microalbuminuria may be not applicable to EH. Instead, a threshold level of ACR greater than or equal to1.5 mg/mmol may be more. appropriate, (C) 2001 American Journal of Hypertension, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:27:41