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Titolo:
Morphology of renal afferent arterioles and glomeruli, heart weight, and blood pressure in primates
Autore:
Skov, K; Hamet, P; Nyengaard, JR; Mulvany, MJ;
Indirizzi:
Aarhus Univ, Dept Pharmacol, DK-8000 Aarhus C, Denmark Aarhus Univ Aarhus Denmark C , Dept Pharmacol, DK-8000 Aarhus C, Denmark Aarhus Univ Hosp, Stereol Res Lab, DK-8000 Aarhus, Denmark Aarhus Univ Hosp Aarhus Denmark DK-8000 Res Lab, DK-8000 Aarhus, Denmark Hop Hotel Dieu, Clin Res Inst Montreal, Montreal, PQ H2W 1T8, Canada Hop Hotel Dieu Montreal PQ Canada H2W 1T8 l, Montreal, PQ H2W 1T8, Canada
Titolo Testata:
AMERICAN JOURNAL OF HYPERTENSION
fascicolo: 4, volume: 14, anno: 2001,
parte:, 1
pagine: 331 - 337
SICI:
0895-7061(200104)14:4<331:MORAAA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; LEFT-VENTRICULAR MASS; CERCOPITHECUS-AETHIOPS; HEMODYNAMICS; HYPERTROPHY; PREVALENCE; LISINOPRIL; MONKEYS; SIZE;
Keywords:
arteriole; glomerulus; blood pressure; left ventricular mass; African green monkey;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Skov, K Aarhus Univ, Dept Pharmacol, Univ Pk 240, DK-8000 Aarhus C, Denmark Aarhus Univ Univ Pk 240 Aarhus Denmark C K-8000 Aarhus C, Denmark
Citazione:
K. Skov et al., "Morphology of renal afferent arterioles and glomeruli, heart weight, and blood pressure in primates", AM J HYPERT, 14(4), 2001, pp. 331-337

Abstract

In a Caribbean outbred population of African green monkeys (Cercopithecus aerhiops), 5 to 10% of feral adults have elevated blood pressure (BP), We have investigated whether the increased pressure is associated with abnormalrenal afferent arteriole structure err glomerular number. In seven young adult (aged 7 to 13 years) male monkeys with consistently high BP (mean BP, 111 mm HE; ketamine anesthesia) and seven controls (mean BP, 81 mm Hg), the. morphology of the renal vasculature has been analyzed in three cortical zones. In each animal, the left kidney vasculature was fixed while relaxed and at known intravascular pressure, and afferent arteriolar diameter and media cross-sectional area were estimated. The right kidney was perfusion-fixed and prepared for unbiased stereo logic estimation of glomerular number and size. No difference was found in afferent arteriole lumen diameter or media cross-sectional area, or in glomerular number or size. between the high BP group and controls. There was no difference in heart weight between the two groups, but there was a negative correlation between left ventricle heart weight and afferent arteriole diameter (controls: r = -0.81, P = .025; all animals: r = -0.70, P = .005, slope about 3.5% reduction in lumen diameter for 19% increase in heart weight). The results suggest that cardiac mass and renal afferent arteriole structure may be controlled by a common mechanism unrelated to BP measured in anesthesia. However, the lack of conscious measurements prevents conclusions as to whether this mechanism involves ambulatory BP. (C) 2001 American Journal of Hypertension, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 12:52:08