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Titolo:
Hepatocellular carcinoma in primary biliary cirrhosis: Similar incidence to that in hepatitis C virus-related cirrhosis
Autore:
Caballeria, L; Pares, A; Castells, A; Gines, A; Bru, C; Rodes, J;
Indirizzi:
Univ Barcelona, Hosp Clin, IDIBAPS, Liver Unit, E-08036 Barcelona, Spain Univ Barcelona Barcelona Spain E-08036 er Unit, E-08036 Barcelona, Spain
Titolo Testata:
AMERICAN JOURNAL OF GASTROENTEROLOGY
fascicolo: 4, volume: 96, anno: 2001,
pagine: 1160 - 1163
SICI:
0002-9270(200104)96:4<1160:HCIPBC>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-HISTORY; RISK-FACTORS; CANCER RISK; PREVALENCE; EXPERIENCE; PROGNOSIS; ALCOHOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Pares, A Univ Barcelona, Hosp Clin, IDIBAPS, Liver Unit, C Villarroel 170,E-08036 Barcelona, Spain Univ Barcelona C Villarroel 170 Barcelona Spain E-08036 a, Spain
Citazione:
L. Caballeria et al., "Hepatocellular carcinoma in primary biliary cirrhosis: Similar incidence to that in hepatitis C virus-related cirrhosis", AM J GASTRO, 96(4), 2001, pp. 1160-1163

Abstract

OBJECTIVES: The prevalence of hepatocellular carcinoma (HCC) in primary biliary cirrhosis (PBC) is not well established, as some reports suggest a low risk, whereas others indicate that HCC may be no less frequent than in other types of cirrhosis. METHODS: We compared the incidence of HCC in a series of 140 patients withPBC (five men, 135 women, mean age 54 +/- 1.6 yr) followed-up for a mean of period of 5.6 +/- 0.4 yr with a group of patients with cirrhosis related to hepatitis C virus (HCV) who were matched for age, sex, and follow-up period. In all patients, HCC was prospectively screened by clinical, laboratory, and ultrasound procedures. RESULTS: Five patients with PBC (3.6%) developed HCC. All were in stage IVof the disease. The incidence of HCC in the 45 patients with late stages of the disease (III or IV) was 11.1%, similar to that found in patients withHCV related cirrhosis. which was 15.0%. The relative risk for HCC in late stages of PBC was of 0.812 (95% CI, 0.229-2.883) with respect to HCV-related cirrhosis. The probability for developing HCC was significantly higher inpatients with HCV-related cirrhosis than in PBC patients overall (p = 0.001), hut was similar in patients with HCV-related cirrhosis and in patients with PBC in stages III and IV (p = ns). CONCLUSION: The risk for HCC in patients with late stages of PBC is similar to that in patients with HCV-related cirrhosis. (Am J Gastroenterol 2001:96: 1160-1163. (C) 2001 by Am. Coll. of Gastroenterology).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 15:25:19